The effects of 1α,25-dihydroxyvitamin D3 on the expression of DNA replication genes

被引：58
|
作者：
Eelen, G
Verlinden, L
Van Camp, M
Van Hummelen, P
Marchal, K
De Moor, B
Mathieu, C
Carmeliet, G
Bouillon, R
Verstuyf, A
机构：
[1] Katholieke Univ Leuven, Lab Expt Geneeskunde Endocrinol, B-3000 Louvain, Belgium
[2] VIB, MicroArray Facil, Louvain, Belgium
[3] Katholieke Univ Leuven, ESAT, SCD, Louvain, Belgium
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 01期
关键词：
vitamin D; osteoblasts; arrays; DNA replication; E2F;
D O I：
10.1359/JBMR.0301204
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To identify key genes in the antiproliferative action of 1,25(OH)(2)D-3, MC3T3-E1 mouse osteoblasts were subjected to cDNA microarray analyses. Eleven E2F-driven DNA replication genes were downregulated by 1,25(OH)(2)D-3. These results were confirmed by quantitative RT-PCR in different cell types, showing the general nature of this action of 1,25(OH)(2)D-3.
引用
收藏
页码：133 / 146
页数：14
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