Five-year results of patients supported by HeartMate II: outcomes and adverse events

被引:17
作者
Hanke, Jasmin S. [1 ]
Rojas, Sebastian V. [1 ]
Mahr, Claudius [2 ]
Schmidt, Anja-Franziska [1 ]
Zoch, Amelie [1 ]
Dogan, Guenes [1 ]
Feldmann, Christina [1 ]
Deniz, Ezin [1 ]
Molitoris, Ullrich [1 ]
Bara, Christoph [1 ]
Struber, Martin [3 ]
Haverich, Axel [1 ]
Schmitto, Jan D. [1 ]
机构
[1] Hannover Med Sch, Dept Cardiac Thorac Transplantat & Vasc Surg, OE 6210,Carl Neuberg Str 1, D-30625 Hannover, Germany
[2] Univ Washington, Med Ctr, Dept Cardiol, Seattle, WA 98195 USA
[3] Richard DeVos Heart & Lung Transplant Clin, Dept Cardiothorac Surg, Grand Rapids, MI USA
关键词
Outcomes; Left ventricular assist device; HeartMate II; Adverse events; Complications; Five years; VENTRICULAR ASSIST DEVICE; CIRCULATORY SUPPORT; INTERAGENCY REGISTRY; PUMP THROMBOSIS; INTERMACS REGISTRY; FAILURE; IMPLANTATION; MULTICENTER; TRANSPLANT; INFECTION;
D O I
10.1093/ejcts/ezx313
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Improved outcomes over the past decade have increased confidence of physicians and patients in extended duration of left ventricular assist device (LVAD) support. This single-centre cohort study reports 5-year outcomes with the HeartMate II (HMII) LVAD. We describe a cohort of 89 patients who received a HMII LVAD between February 2004 and December 2010. The causes of death and adverse events were assessed by examination of medical records. A total of 202.74 patient-years were analysed. After 5 years, of the 89 patients, 15 patients remained on device therapy, 39 patients died, 28 patients underwent heart transplantation and 7 patients underwent explantation of the HMII for recovery. One year after the HMII implantation, there was a survival of 71% in the study cohort. In the following years, the survival rate was 65% in the 2nd year, 63% in the 3rd year, 56% in the 4th year and 54% after 5 years of LVAD support. Ten LVAD exchanges were performed in 8 (11%) patients. Currently (March 2017), 12 patients still remain on their original device. The longest ongoing patient on the HMII has been supported for over 11 years (4097 days). The most common adverse events were bleeding (68%; 1.5837 events per patient-year) and LVAD infection [49%; 1.0666 events per patient-year]. Seven cases of pump thrombosis were described (8%; 0.1131 events per patient-year). This is the first single-cohort study to describe a 5-year survival of HMII patients on extended duration of support. A 5-year survival of 54% was observed in this single-centre cohort.
引用
收藏
页码:422 / 427
页数:6
相关论文
共 29 条
  • [1] LVAD destination therapy: applying what we know about psychiatric evaluation and management from cardiac failure and transplant
    Eshelman, Anne K.
    Mason, Shawn
    Nemeh, Hassan
    Williams, Celeste
    [J]. HEART FAILURE REVIEWS, 2009, 14 (01) : 21 - 28
  • [2] Continuous-flow devices and percutaneous site infections: Clinical outcomes
    Goldstein, Daniel J.
    Naftel, David
    Holman, William
    Bellumkonda, Lavanya
    Pamboukian, Salpy V.
    Pagani, Francis D.
    Kirklin, James
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2012, 31 (11) : 1151 - 1157
  • [3] Viennese approach to minimize the invasiveness of ventricular assist device implantation
    Haberl, Thomas
    Riebandt, Julia
    Mahr, Stephane
    Laufer, Guenther
    Rajek, Angela
    Schima, Heinrich
    Zimpfer, Daniel
    [J]. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014, 46 (06) : 991 - 996
  • [4] Minimally-invasive LVAD Implantation: State of the Art
    Hanke, Jasmin S.
    Rojas, Sebastian V.
    Avsar, Murat
    Haverich, Axel
    Schmitto, Jan D.
    [J]. CURRENT CARDIOLOGY REVIEWS, 2015, 11 (03) : 246 - 251
  • [5] What is the truth behind pump thrombosis in the HeartMate II device? A National Heart, Lung, and Blood Institute perspective based on data from the Interagency Registry for Mechanically Assisted Circulatory Support
    Jeffries, Neal
    Miller, Marissa A.
    Taddei-Peters, Wendy C.
    Burke, Catherine
    Baldwin, J. Timothy
    Young, James B.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2015, 34 (12) : 1505 - 1510
  • [6] Results of the Destination Therapy Post-Food and Drug Administration Approval Study With a Continuous Flow Left Ventricular Assist Device A Prospective Study Using the INTERMACS Registry (Interagency Registry for Mechanically Assisted Circulatory Support)
    Jorde, Ulrich P.
    Kushwaha, Sudhir S.
    Tatooles, Antone J.
    Naka, Yoshifumi
    Bhat, Geetha
    Long, James W.
    Horstmanshof, Douglas A.
    Kormos, Robert L.
    Teuteberg, Jeffrey J.
    Slaughter, Mark S.
    Birks, Emma J.
    Farrar, David J.
    Park, Soon J.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (17) : 1751 - 1757
  • [7] Safety of reduced anti-thrombotic strategies in Heart Mate II patients: A one-year analysis of the US-TRACE Study
    Katz, Jason N.
    Adamson, Robert M.
    John, Ranjit
    Tatooles, Antone
    Sundareswaran, Kartik
    Kallel, Faouzi
    Farrar, David J.
    Jorde, Ulrich P.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2015, 34 (12) : 1542 - 1548
  • [8] Pump thrombosis in the Thoratec HeartMate II device: An update analysis of the INTERMACS Registry
    Kirklin, James K.
    Naftel, David C.
    Pagani, Francis D.
    Kormos, Robert L.
    Myers, Susan
    Acker, Michael. A.
    Rogers, Joseph
    Slaughter, Mark S.
    Stevenson, Lynne W.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2015, 34 (12) : 1515 - 1526
  • [9] Psychosocial assessment of candidates and risk classification of patients considered for durable mechanical circulatory support
    Maltby, Megan C.
    Flattery, Maureen P.
    Burns, Brigid
    Salyer, Jeanne
    Weinland, Stephan
    Shah, Keyur B.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2014, 33 (08) : 836 - 841
  • [10] Results of mechanical circulatory support in France
    Mazzucotelli, Jean-Philippe
    Leprince, Pascal
    Litzler, Pierre-Yves
    Vincentelli, Andre
    Le Guyader, Alexandre
    Kirsch, Matthias
    Camilleri, Lionel
    Flecher, Erwan
    [J]. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2011, 40 (03) : E112 - E117