Effect of Biodegradable Scleral Plugs Containing Curcumin on Proliferative Vitreoretinopathy

被引：6
作者：
Zhang, Jun [1 ]
Zhou, Nalei [2 ]
Zhang, Bin [2 ]
Ma, Jingxue [2 ]
机构：
[1] Hebei Med Univ, Hosp 3, Ophthalmol Dept, Shijiazhuang, Hebei, Peoples R China
[2] Hebei Med Univ, Hosp 2, Ophthalmol Dept, 215 West Heping Rd, Shijiazhuang 050051, Hebei, Peoples R China
来源：
OPHTHALMIC RESEARCH | 2018年 / 59卷 / 01期
关键词：
Curcumin; Proliferative vitreoretinopathy; Inflammatory factors; Biodegradable scleral plugs; RETINAL-DETACHMENT; PLGA NANOPARTICLES; TNF-ALPHA; CELLS; FORMULATION; ACTIVATION; EXPRESSION; FAILURE; SURGERY; TARGETS;
D O I：
10.1159/000450553
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Background: This study aimed to explore the inhibitory effect of biodegradable scleral plugs containing curcumin on rabbits with proliferative vitreoretinopathy (PVR). Materials and Methods: The biodegradable scleral plugs containing curcumin were prepared by dissolving PLGA [poly(lactide-co-glycolide)] and curcumin. In total, 30 rabbits were divided into 2 groups: the model group received a vitreous injection of self-blood, and the treatment group received a vitreous injection of self-blood plus biodegradable scleral implants containing 1.5 mg of curcumin. On days 1, 3, 7, 14, 21, and 28 after the operation, clinical observations and PVR classifications were performed. Then, after vitreous samples were collected, different cytokines were detected using antibody chip technology. Results: The scleral plug was 5 mm in length and 1 mm in diameter. Clinical observation showed marked inflammation in the model group. The development grade of PVR in the treatment group was lower than that in the model group (p < 0.05). The outcome of antibody chip technology showed that the expression levels of IL-1 alpha, IL-1 beta, IL-8, leptin, MMP-9, NCAM, and TNF-alpha in the treatment group at different time points were significantly lower than those in the model group (p < 0.05). Conclusion: Curcumin might have great potential as a therapeutic agent for PVR by inhibiting various inflammatory factors. (C) 2017 S. Karger AG, Basel
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页码：30 / 36
页数：7
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