Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods

被引：17
作者：
Chen, Ying [1 ,2 ,3 ]
You, Ruya [1 ,2 ,3 ]
Wang, Ke [1 ,2 ,3 ]
Wang, Yousheng [1 ,2 ,3 ]
机构：
[1] Beijing Technol & Business Univ BTBU, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China
[2] Rizhao HUAWEI Inst Comprehens Hlth Ind, Rizhao, Shandong, Peoples R China
[3] Shandong KEEPFIT Biotech Co Ltd, Rizhao, Shandong, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
URIC-ACID TRANSPORTER; XANTHINE-OXIDASE; HYPERURICEMIA; MECHANISM; DIOSCIN; KIDNEY; RISK; GOUT; IDENTIFICATION; METABOLISM;
D O I：
10.1155/2021/5738900
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interest in discovering new URAT1 inhibitors and developing technology that can evaluate URAT1 inhibition. This review summarizes the methods for assay of URAT1 inhibition and the progress on the discovery of natural and synthetic URAT1 inhibitors in the past five years.
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页数：12
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