Genetic analysis of 17 Y-chromosomal STRs haplotypes of Chinese Tibetan ethnic group residing in Qinghai province of China

被引：53
作者：
Zhu, Bofeng [1 ,2 ]
Wu, Yuanming [3 ]
Shen, Chunmei [1 ,4 ]
Yang, Tiehong [5 ]
Deng, Yajun [6 ,7 ]
Xun, Xi [1 ,2 ]
Tian, Yingfang [1 ,2 ]
Yan, Jincheng [1 ,2 ]
Li, Tao [1 ,2 ]
机构：
[1] Xian Jiaotong Univ, Minist Educ, Lab Environm & Gene Related Dis, Xian 710061, Shaanxi, Peoples R China
[2] Xian Jiaotong Univ, Dept Forens Med, Sch Med, Xian 710061, Shaanxi, Peoples R China
[3] Fourth Mil Med Univ, Fmmu Ctr DNA Typing, Dept Pathophysiol, Xian 710032, Peoples R China
[4] Inst Xian Blood Bank, Ctr Shaanxi Blood Bank, Xian 710061, Peoples R China
[5] Fourth Mil Med Univ, Dept Pharmacol, Sch Pharm, Xian 710032, Peoples R China
[6] Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China
[7] Chinese Acad Sci, Ctr Forens Sci, Beijing Genom Inst, Beijing 101300, Peoples R China
来源：
FORENSIC SCIENCE INTERNATIONAL | 2008年 / 175卷 / 2-3期
基金：
中国国家自然科学基金;
关键词：
Y-chromosomal STRs; haplotype; Chinese Tibetan ethnic minority group; AmpFLSTR Y-filer kit;
D O I：
10.1016/j.forsciint.2007.06.012
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
We have co-amplified and analyzed 17 Y-chromosomal STRs loci including European 'extended haplotypes' (DYS 19, DYS389 I, DYS389 II, DYS390. DYS391, DYS392, DYS393, DYS385a,b, DYS438, and DYS439) and also six additional loci DYS437, DYS448, DYS456, DYS458, DYS635 and YGATA H4 in a population sample of 167 healthy unrelated autochthonous male individuals of Chinese Tibetan ethnic minority group residing in Qinghai province of China using a multiplex PCR system. The gene diversity values for the Y-STRs loci ranged from a minimum 0.3581 for DYS391 locus to a maximum of 0.8702 for DYS385a,b loci in Tibetan population. A total of 163 haplotypes were identified in the set of Y-STR loci, of which 159 were unique and 4 found in two individuals. The overall haplotype diversity for the set of Y-STRs loci was 0.9998, and the discrimination capacity was 0.9938. Research results will be valuable for human identification and paternity tests in the region and for Chinese population genetic study in the future. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：238 / 243
页数：6
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