Assignment of the 15N Resonances of the Antifungal Agent Posaconazole

被引：10

作者：

Hilton, Bruce D. ^{[1
]}

Feng, Wenqing ^{[1
]}

Martin, Gary E. ^{[1
]}

机构：

[1] Merck Res Labs, Discovery & Preclin Sci, Proc Chem Rapid Struct Characterizat Lab, Summit, NJ 07901 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2011年 / 48卷 / 04期

关键词：

NMR-SPECTROSCOPY; IN-VITRO; ITRACONAZOLE; TECHNOLOGY; SCH-56592;

D O I：

10.1002/jhet.665

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structurally complex antifungal agent posaconazole has been well characterized by conventional H-1- and C-13-NMR studies. In contrast, N-15 resonance assignments have never been reported. We now wish to report the assignment of the eight N-15 resonances of posaconazole using two-dimensional long-range H-1-N-15 GHMBCAD NMR data. The N-15 resonance assignments were undertaken to facilitate the evaluation of the impact of H-1-N-15 heteronuclear shift correlation data in the Computer-Assisted Structure Elucidation (CASE) of complex molecular structures.

引用

页码：948 / 951

页数：4

共 22 条

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