ISOLATION OF PEPTIDOLIPIN NA DERIVATIVES FROM THE CULTURE OF NOCARDIA ARTHRITIDIS IFM10035T IN THE PRESENCE OF MOUSE MACROPHAGE CELLS

被引：7

作者：

Hara, Yasumasa ^{[1
,2
]}

Tanimura, Daiki ^{[1
]}

Manome, Teruhisa ^{[1
]}

Arai, Midori A. ^{[3
]}

Yaguchi, Takashi ^{[4
]}

Ishibashi, Masami ^{[1
,2
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 1-8-1 Inohana, Chiba 2608675, Japan

[2] Chiba Univ, Plant Mol Sci Ctr, Chuo Ku, 1-8-1 Inohana, Chiba 2608675, Japan

[3] Keio Univ, Fac Sci & Technol, Dept Biosci & Informat, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan

[4] Chiba Univ, Med Mycol Res Ctr, Chuo Ku, 1-8-1 Inohana, Chiba 2608673, Japan

来源：

HETEROCYCLES | 2022年 / 104卷 / 01期

基金：

日本学术振兴会;

关键词：

D O I：

10.3987/COM-21-14567

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We isolated two peptidolipin NA derivatives, L-Val (6) peptidolipin NA and peptidolipin NA, named as compounds 1 and 2, respectively. These compounds were produced in the co-culture extracts of Nocardia arthritidis IFM10035(T)and the mouse macrophage cell line J774.1, but not in the single culture of N. arthritidis. Among the two compounds along with nocarjamide (3) isolated from the co-culture of N. tenerifensis and J774.1, compounds 1 and 3 showed higher cytotoxicity against J774.1, with IC50 values of 116 mu M and 25 mu M, respectively. In addition, compound 1 showed a TRAIL-resistance-overcoming activity in the human gastric adenocarcinoma AGS cells.

引用

页码：185 / 190

页数：6

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