Cellular Plasticity in Intestinal Homeostasis and Disease

被引：125
作者：
de Sousa e Melo, Felipe [1 ]
de Sauvage, Frederic J. [2 ]
机构：
[1] Genentech Inc, Discovery Oncol, San Francisco, CA 94080 USA
[2] Genentech Inc, Mol Oncol, San Francisco, CA 94080 USA
来源：
CELL STEM CELL | 2019年 / 24卷 / 01期
关键词：
LABEL-RETAINING CELLS; LGR5(+) STEM-CELLS; WNT/BETA-CATENIN; HUMAN COLON; IN-VIVO; SECRETORY PRECURSORS; PROLIFERATIVE CELLS; COLORECTAL-CANCER; WNT; CRYPT;
D O I：
10.1016/j.stem.2018.11.019
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The intestinal epithelium is one the fastest renewing tissues in mammals and is endowed with extensive adaptability. The more traditional view of a hierarchical organization of the gut has recently given way to a more dynamic model in which various cell types within the intestinal epithelium can de-differentiate and function as an alternative source of stem cells upon tissue damage and stress conditions such as inflammation and tumorigenesis. Here, we will review the mechanistic principles and key players involved in intestinal plasticity and discuss potential therapeutic implications of cellular plasticity in regenerative medicine and cancer.
引用
收藏
页码：54 / 64
页数：11
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