Resveratrol and red wine, healthy heart and longevity (vol 15, pg 467, 2010)

被引：21
作者：
Das, Dipak K. [1 ]
Mukherjee, Subhendu [1 ]
Ray, Diptarka [1 ]
机构：
[1] Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA
来源：
HEART FAILURE REVIEWS | 2011年 / 16卷 / 04期
关键词：
Resveratrol; Red wine; White wine; Cardioprotection; Longevity genes; Anti-aging; SIRT; FoxO; PBEF; PROSTAGLANDIN E-2 PRODUCTION; SMALL-MOLECULE ACTIVATORS; COLONY-ENHANCING FACTOR; OXIDATIVE DNA-DAMAGE; FACTOR-KAPPA-B; LIFE-SPAN; CELL-SURVIVAL; CAENORHABDITIS-ELEGANS; NUCLEAR TRANSLOCATION; CALORIE RESTRICTION;
D O I：
10.1007/s10741-011-9234-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.
引用
收藏
页码：425 / 435
页数：11
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