Resveratrol and red wine, healthy heart and longevity (vol 15, pg 467, 2010)

被引：22

作者：

Das, Dipak K. ^{[1
]}

Mukherjee, Subhendu ^{[1
]}

Ray, Diptarka ^{[1
]}

机构：

[1] Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA

来源：

HEART FAILURE REVIEWS | 2011年 / 16卷 / 04期

关键词：

Resveratrol; Red wine; White wine; Cardioprotection; Longevity genes; Anti-aging; SIRT; FoxO; PBEF; PROSTAGLANDIN E-2 PRODUCTION; SMALL-MOLECULE ACTIVATORS; COLONY-ENHANCING FACTOR; OXIDATIVE DNA-DAMAGE; FACTOR-KAPPA-B; LIFE-SPAN; CELL-SURVIVAL; CAENORHABDITIS-ELEGANS; NUCLEAR TRANSLOCATION; CALORIE RESTRICTION;

D O I：

10.1007/s10741-011-9234-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.

引用

页码：425 / 435

页数：11

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