Palladium-Catalyzed Oxidative sp2 C-H Bond Acylation with Alcohols

被引：167
作者：
Xiao, Fuhong [1 ]
Qi Shuai [2 ]
Zhao, Feng [1 ]
Basle, Olivier [2 ]
Deng, Guojun [1 ]
Li, Chao-Jun [2 ]
机构：
[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China
[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 07期
基金：
中国国家自然科学基金;
关键词：
DIRECT ARYLATION; 2-ARYLPYRIDINE DERIVATIVES; COUPLING REACTIONS; FUNCTIONALIZATION; ACTIVATION; ARENES; CARBON; CONSTRUCTION; HETEROCYCLES; AMINATION;
D O I：
10.1021/ol200017a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method was developed for the direct acylation of arene sp(2) C-H bonds with alcohols using palladium chloride as a catalyst and peroxide as the oxidant. The alcohols were oxidized to their corresponding aldehydes in situ and efficiently coupled with 2-arylpyridines to give aryl ketones in chlorobenzene.
引用
收藏
页码：1614 / 1617
页数：4
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