Palladium-Catalyzed Oxidative sp2 C-H Bond Acylation with Alcohols

被引：167

作者：

Xiao, Fuhong ^{[1
]}

Qi Shuai ^{[2
]}

Zhao, Feng ^{[1
]}

Basle, Olivier ^{[2
]}

Deng, Guojun ^{[1
]}

Li, Chao-Jun ^{[2
]}

机构：

[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China

[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 07期

基金：

中国国家自然科学基金;

关键词：

DIRECT ARYLATION; 2-ARYLPYRIDINE DERIVATIVES; COUPLING REACTIONS; FUNCTIONALIZATION; ACTIVATION; ARENES; CARBON; CONSTRUCTION; HETEROCYCLES; AMINATION;

D O I：

10.1021/ol200017a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method was developed for the direct acylation of arene sp(2) C-H bonds with alcohols using palladium chloride as a catalyst and peroxide as the oxidant. The alcohols were oxidized to their corresponding aldehydes in situ and efficiently coupled with 2-arylpyridines to give aryl ketones in chlorobenzene.

引用

页码：1614 / 1617

页数：4

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