Pre- versus post-column oxidation liquid chromatography fluorescence detection of paralytic shellfish toxins

被引：25

作者：

DeGrasse, Stacey L. ^{[1
]}

van de Riet, Jeffrey ^{[2
]}

Hatfield, Robert ^{[3
]}

Turner, Andrew ^{[3
]}

机构：

[1] US FDA, Ctr Food Safety & Appl Nutr, Off Regulatory Sci, Div Analyt Chem,Spect & Mass Spectrometry Branch, College Pk, MD 20740 USA

[2] Canadian Food Inspect Agcy, Dartmouth Lab, Dartmouth, NS B3B 1Y9, Canada

[3] Ctr Environm Fisheries & Aquaculture Sci, Weymouth DT4 8UB, Dorset, England

来源：

TOXICON | 2011年 / 57卷 / 04期

关键词：

LC; Oxidation; Paralytic shellfish toxins; Saxitoxin; Validation; POISONING TOXINS; PRECHROMATOGRAPHIC OXIDATION; QUANTITATIVE-DETERMINATION; ALEXANDRIUM; GULF; MUSSELS; OYSTERS; CLAMS; PSP;

D O I：

10.1016/j.toxicon.2010.12.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Both pre- and post-column oxidation liquid chromatography methods with fluorescence detection are available for detecting paralytic shellfish toxins. Each method has been evaluated in multiple laboratories and validated as a potential alternative to the mouse bioassay. This communication compares the advantages and limitations of both methods. For a given laboratory, the selection of either method may be based primarily on practicality and less on any deficiencies in scientific merit. Published by Elsevier Ltd.

引用

页码：619 / 624

页数：6

共 30 条

[1] BIOGEOGRAPHY OF TOXIC DINOFLAGELLATES IN THE GENUS ALEXANDRIUM FROM THE NORTHEASTERN UNITED-STATES AND CANADA [J].