Subversion of myosin function by E.coli

被引：3

作者：

Mattoo, Seenna ^{[1
]}

Alto, Neal M. ^{[3
]}

Dixon, Jack E. ^{[1
,2
]}

机构：

[1] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[2] Univ Calif San Diego, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA

[3] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

来源：

DEVELOPMENTAL CELL | 2008年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.devcel.2007.12.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Enteropathogenic E. coli establish close contact with host cells by nucleating localized actin rearrangements and directly evading phagocytosis. lizumi et al. now show in a recent issue of Cell Host and Microbe that the type III secretion effector EspB, initially thought to be involved in the translocation of other bacterial effectors, mediates antiphagocytosis and microvilli lesions by inhibiting myosin function.

引用

页码：8 / 10

页数：3

共 10 条

[1] Subversion of actin dynamics by EPEC and EHEC
Caron, E
Crepini, VF
Simpson, N
Knutton, S
Garmendia, J
Frankel, G
[J]. CURRENT OPINION IN MICROBIOLOGY, 2006, 9 (01) : 40 - 45
[2] Freeman NL, 2000, CELL MOTIL CYTOSKEL, V47, P307, DOI 10.1002/1097-0169(200012)47:4<307::AID-CM5>3.0.CO
[3] 2-Q
[4] Enteropathogenic Escherichia coli inhibits phagocytosis
Goosney, DL
Celli, J
Kenny, B
Finlay, BB
[J]. INFECTION AND IMMUNITY, 1999, 67 (02) : 490 - 495
[5] The enteropathogenic E-coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function
Iizumi, Yosuke
Sagara, Hiroshi
Kabe, Yasuaki
Azuma, Motoki
Kume, Kanako
Ogawa, Michinaga
Nagai, Takeshi
Gillespie, Peter G.
Sasakawa, Chihiro
Handa, Hiroshi
[J]. CELL HOST & MICROBE, 2007, 2 (06) : 383 - 392
[6] α1-antitrypsin binds to and interferes with functionality of EspB from atypical and typical enteropathogenic Escherichia coli strains
Knappstein, S
Ide, T
Schmidt, MA
Heusipp, G
[J]. INFECTION AND IMMUNITY, 2004, 72 (08) : 4344 - 4350
[7] Swanson JA, 1999, J CELL SCI, V112, P307
[8] Expression of the EspB protein of enteropathogenic Escherichia coli within HeLa cells affects stress fibers and cellular morphology
Taylor, KA
Luther, PW
Donnenberg, MS
[J]. INFECTION AND IMMUNITY, 1999, 67 (01) : 120 - 125
[9] Myosin-1a is critical for normal brush border structure and composition
Tyska, MJ
Mackey, AT
Huang, JD
Copeland, NG
Jenkins, NA
Mooseker, MS
[J]. MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (05) : 2443 - 2457
[10] Type III secretion-dependent hemolytic activity of enteropathogenic Escherichia coli
Warawa, J
Finlay, BB
Kenny, B
[J]. INFECTION AND IMMUNITY, 1999, 67 (10) : 5538 - 5540

← 1 →