A mycobacterial smc null mutant is proficient in DNA repair and long-term survival

被引：18
作者：
Guethlein, Carolin [1 ,2 ]
Wanner, Roger M. [1 ,2 ]
Sander, Peter [1 ,2 ]
Boettger, Erik C. [1 ,2 ]
Springer, Burkhard [1 ,2 ]
机构：
[1] Univ Zurich, Inst Med Mikrobiol, CH-8006 Zurich, Switzerland
[2] Natl Zentrum Mykobakterien, CH-8006 Zurich, Switzerland
来源：
JOURNAL OF BACTERIOLOGY | 2008年 / 190卷 / 01期
关键词：
D O I：
10.1128/JB.01315-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
SMC (structural maintenance of chromosomes) proteins play fundamental roles in various aspects of chromosome organization and dynamics, including repair of DNA damage. Mutant strains of Mycobacterium smegmatis and Mycobacterium tuberculosis defective in SMC were constructed. Surprisingly, inactivation of smc did not result in recognizable phenotypes in hallmark assays characteristic for the function of these genes. This is in contrast to data for smc null mutants in other species.
引用
收藏
页码：452 / 456
页数：5
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