Role of intracellular calcium in peroxide-induced potentiation of norepinephrine release from bovine isolated irides

被引：7

作者：

Opere, CA

Ohia, SE

机构：

[1] Creighton Univ, Ctr Hlth Sci, Dept Pharmaceut, Omaha, NE 68178 USA

[2] Creighton Univ, Ctr Hlth Sci, Dept Adm Sci & Pharmacol, Omaha, NE 68178 USA

来源：

GENERAL PHARMACOLOGY | 1998年 / 31卷 / 05期

关键词：

hydrogen peroxide; intracellular calcium; bovine iris; norepinephrine release; calcium channel antagonists; oxidative stress;

D O I：

10.1016/S0306-3623(98)00090-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. BAPTA AM (10 mu M), thapsigargin (10 mu M), ruthenium red (30 mu M) and oligomycin (30 mu M) inhibited field stimulated [H-3]NE release from bovine isolated irides by 54%, 30%, 30% and 26%, respectively. 2. Both BAPTA AM and thapsigargin had no significant effect (P > 0.05) on H2O2-induced potentiation of evoked [H-3]NE release. 3. Ruthenium red prevented (but oligomycin enhanced) H2O2-induced enhancement of evoked [H-3]NE release. 4. We conclude that, although intracellular calcium participates in field-stimulation evoked [H-3]NE release from bovine isolated irides, only the mitochondrial pool of calcium may be involved in peroxide-induced enhancement of sympathetic neurotransmission. (C) 1998 Elsevier Science Inc.

引用

页码：793 / 798

页数：6

共 34 条

[1] CA-2+(0)-INDEPENDENT VERATRIDINE-EVOKED ACETYLCHOLINE-RELEASE FROM STRIATAL SLICES IS NOT INHIBITED BY VESAMICOL (AH5183) - MOBILIZATION OF DISTINCT TRANSMITTER POOLS [J].