DNA methylation in Schwann cells and in oligodendrocytes

被引：14

作者：

Arthur-Farraj, Peter ^{[1
]}

Moyon, Sarah ^{[2
]}

机构：

[1] Univ Cambridge, Dept Clin Neurosci, John Van Geest Ctr Brain Repair, Robinson Way, Cambridge CB2 0PY, England

[2] CUNY, Neurosci Initiat Adv Sci Res Ctr, 85 St Nicholas Terrace, New York, NY 10031 USA

来源：

GLIA | 2020年 / 68卷 / 08期

基金：

欧洲研究理事会;

关键词：

aging; demyelination; DNA methylation; epigenetics; glioma; oligodendrocyte; Schwann cell; Schwannomas; ISOCITRATE-DEHYDROGENASE; 1; GENOME-WIDE METHYLATION; CPG ISLAND METHYLATION; PROMOTER METHYLATION; MULTIPLE-SCLEROSIS; WHITE-MATTER; PROGENITOR CELLS; GENE-EXPRESSION; NF1; PROMOTER; EPIGENETIC REGULATION;

D O I：

10.1002/glia.23784

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

DNA methylation is one of many epigenetic marks, which directly modifies base residues, usually cytosines, in a multiple-step cycle. It has been linked to the regulation of gene expression and alternative splicing in several cell types, including during cell lineage specification and differentiation processes. DNA methylation changes have also been observed during aging, and aberrant methylation patterns have been reported in several neurological diseases. We here review the role of DNA methylation in Schwann cells and oligodendrocytes, the myelin-forming glia of the peripheral and central nervous systems, respectively. We first address how methylation and demethylation are regulating myelinating cells' differentiation during development and repair. We then mention how DNA methylation dysregulation in diseases and cancers could explain their pathogenesis by directly influencing myelinating cells' proliferation and differentiation capacities.

引用

页码：1568 / 1583

页数：16

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