Optimal evaluation of single-molecule force spectroscopy experiments

被引:18
作者
Getfert, Sebastian [1 ]
Reimann, Peter [1 ]
机构
[1] Univ Bielefeld, Fak Phys, D-33615 Bielefeld, Germany
来源
PHYSICAL REVIEW E | 2007年 / 76卷 / 05期
关键词
D O I
10.1103/PhysRevE.76.052901
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
The forced rupture of single chemical bonds under external load is addressed. A general framework is put forward to optimally utilize the experimentally observed rupture force data for estimating the parameters of a theoretical model. As an application, we explore to what extent a distinction between several recently proposed models is feasible on the basis of realistic experimental data sets.
引用
收藏
页数:4
相关论文
共 25 条
[1]  
[Anonymous], 1999, Mathematical Methods of Statistics
[2]   Dynamic response of adhesion complexes: Beyond the single-path picture [J].
Bartolo, Denis ;
Derényi, Imre ;
Ajdari, Armand .
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 2002, 65 (05) :1-051910
[3]  
BELL GI, 1978, SCIENCE, V200, P618, DOI 10.1126/science.347575
[4]  
Cover TM, 2006, Elements of Information Theory
[5]   Bayesian inference in processing experimental data: principles and basic applications [J].
D'Agostini, G .
REPORTS ON PROGRESS IN PHYSICS, 2003, 66 (09) :1383-1419
[6]   Bayesian inference in physics: case studies [J].
Dose, V .
REPORTS ON PROGRESS IN PHYSICS, 2003, 66 (09) :1421-1461
[7]   Intrinsic rates and activation free energies from single-molecule pulling experiments [J].
Dudko, OK ;
Hummer, G ;
Szabo, A .
PHYSICAL REVIEW LETTERS, 2006, 96 (10)
[8]   Beyond the conventional description of dynamic force spectroscopy of adhesion bonds [J].
Dudko, OK ;
Filippov, AE ;
Klafter, J ;
Urbakh, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) :11378-11381
[9]   Dynamic strength of molecular adhesion bonds [J].
Evans, E ;
Ritchie, K .
BIOPHYSICAL JOURNAL, 1997, 72 (04) :1541-1555
[10]   Probing the relation between force - Lifetime - and chemistry in single molecular bonds [J].
Evans, E .
ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2001, 30 :105-128