Hypersomnia and low CSF hypocretin-1 (orexin-A) concentration in a patient with multiple sclerosis showing bilateral hypothalamic lesions

被引：40
|
作者：
Kato, T
Kanbayashi, T
Yamamoto, K
Nakano, T
Shimizu, T
Hashimoto, T
Ikeda, S
机构：
[1] Shinshu Univ, Sch Med, Dept Internal Med 3, Matsumoto, Nagano 3908621, Japan
[2] Akita Univ, Sch Med, Dept Neuropsychiat, Akita 010, Japan
[3] Toyoshina Red Cross Hosp, Dept Neurol, Nagano, Japan
来源：
INTERNAL MEDICINE | 2003年 / 42卷 / 08期
关键词：
multiple sclerosis; hypersomnia; hypocrein; orexin; hypothalamus;
D O I：
10.2169/internalmedicine.42.743
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 45-year-old Japanese woman with multiple sclerosis (MS) manifested hypersomnia in a relapse of MS. Magnetic resonance imaging revealed new bilateral hypothalamic lesions, and the hypocretin-1 level in the cerebrospinal fluid (CSF) was significantly low. Methylprednisolone pulse treatment successfully resolved the hypersomnia and the left hypothalamic lesion, and it normalized the hypocretin-1 level in the CSF. These findings suggest that the hypothalamic hypocretin (orexin) system may be crucial to maintaining the arousal level and that lesions in the system can cause hypersomnia in MS.
引用
收藏
页码：743 / 745
页数：3
相关论文
共 38 条
  • [21] The significance of CSF hypocretin-1 (Orexin-A) measurement in pediatric and adolescent neurologic disorders
    Arii, J
    Kanbayashi, T
    Sawaishi, Y
    Yano, T
    Kimura, S
    Hishikawa, Y
    Takahashi, Y
    Shimizu, Y
    Tanabe, Y
    Nishino, S
    SLEEP, 2003, 26 : A129 - A130
  • [22] Narcolepsy without cataplexy: 2 subtypes based on CSF hypocretin-1/Orexin-A findings
    Oka, Yasunori
    Inoue, Yuichi
    Kanbayashi, Takashi
    Kuroda, Kenji
    Miyamoto, Masayuki
    Miyamoto, Tomoyuki
    Ikeda, Akio
    Shimizu, Tetsuo
    Hishikawa, Yasuo
    Shibasaki, Hiroshi
    SLEEP, 2006, 29 (11) : 1439 - 1443
  • [23] Decreased CSF hypocretin-1 (orexin-A) in patients after acute haemorrhagic brain stroke
    Rejdak, K
    Petzold, A
    Lin, L
    Smith, M
    Kitchen, N
    Grieb, P
    Stelmasiak, Z
    Thompson, EJ
    JOURNAL OF NEUROLOGY, 2005, 252 : 8 - 8
  • [24] Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers
    John, J
    Wu, MF
    Maidment, NT
    Lam, HA
    Boehmer, LN
    Patton, M
    Siegel, JM
    JOURNAL OF PHYSIOLOGY-LONDON, 2004, 560 (02): : 587 - 592
  • [25] Hypocretin-1 (Orexin-A) levels in human lumbar CSF in different age groups: Infants to elderly persons
    Kanbayashi, T
    Yano, T
    Ishiguro, H
    Kawanishi, K
    Chiba, S
    Aizawa, R
    Sawaishi, Y
    Hirota, K
    Nishino, S
    Shimizu, T
    SLEEP, 2002, 25 (03): : 337 - 339
  • [26] Hypocretin-1 (orexin-A) concentrations in cerebrospinal fluid are low in patients with Guillain-Barre syndrome
    Kanbayashi, T
    Ishiguro, H
    Aizawa, R
    Saito, Y
    Ogawa, Y
    Abe, M
    Hirota, K
    Nishino, S
    Shimizu, T
    PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2002, 56 (03) : 273 - 274
  • [27] CSF hypocretin-1 concentrations correlate with the level of fatigue in multiple sclerosis patients
    Papuc, Ewa
    Zbigniew, Stelmasiak
    Pawel, Grieb
    Konrad, Rejdak
    NEUROSCIENCE LETTERS, 2010, 474 (01) : 9 - 12
  • [28] Low cerebrospinal fluid and plasma orexin-A (hypocretin-1) concentrations in combat-related posttraumatic stress disorder
    Strawn, Jeffrey R.
    Pyne-Geithman, Gail J.
    Ekhator, Nosakhare N.
    Horn, Paul S.
    Uhde, Thomas W.
    Shutter, Lori A.
    Baker, Dewleen G.
    Geracioti, Thomas D., Jr.
    PSYCHONEUROENDOCRINOLOGY, 2010, 35 (07) : 1001 - 1007
  • [29] Increased daytime sleepiness and low hypocretin-1 during attacks of multiple sclerosis?
    Knudsen, S.
    Jennion, P.
    Korsholm, K.
    Sheikli, S.
    Gammeltoft, S.
    Frederiksen, I. L.
    MULTIPLE SCLEROSIS, 2007, 13 : S249 - S250
  • [30] Excessive daytime sleepiness and low CSF hypocretin-I (Orexin-A) levels in a patient of with probable progressive supranuclear palsy
    Hattori, Y
    Hattori, T
    Mukai, E
    Mori, H
    Mizuno, Y
    Kayukawa, Y
    Okada, T
    Kanbayashi, T
    SLEEP, 2004, 27 : 316 - 316
1234