Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice

被引：16

作者：

Longo, Beatriz ^{[1
]}

Romariz, Simone ^{[1
]}

Blanco, Miriam Marcela ^{[1
]}

Vasconcelos, Juliana Fraga

Bahia, Luciana

Pereira Soares, Milena Botelho ^{[2
]}

Mello, Luiz E. ^{[1
]}

Ribeiro-dos-Santos, Ricardo ^{[2
]}

机构：

[1] Univ Fed Sao Paulo, Dept Fisiol, Lab Neurofisiol, Sao Paulo, Brazil

[2] Hosp Sao Rafael, Ctr Biotecnol & Terapia Celular, BR-41253190 Salvador, BA, Brazil

来源：

EPILEPSIA | 2010年 / 51卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

Hippocampus; Chimeric mice; Microglia; Status epilepticus; GFP; CENTRAL-NERVOUS-SYSTEM; NEUROGENESIS; MECHANISMS; MICROGLIA; SEIZURES; EPILEPSY;

D O I：

10.1111/j.1528-1167.2010.02570.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

P>The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP+ bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. The pattern of distribution, proliferation, and differentiation of GFP+ cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.

引用

页码：1628 / 1632

页数：5

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