Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice

被引：16
作者：
Longo, Beatriz [1 ]
Romariz, Simone [1 ]
Blanco, Miriam Marcela [1 ]
Vasconcelos, Juliana Fraga
Bahia, Luciana
Pereira Soares, Milena Botelho [2 ]
Mello, Luiz E. [1 ]
Ribeiro-dos-Santos, Ricardo [2 ]
机构：
[1] Univ Fed Sao Paulo, Dept Fisiol, Lab Neurofisiol, Sao Paulo, Brazil
[2] Hosp Sao Rafael, Ctr Biotecnol & Terapia Celular, BR-41253190 Salvador, BA, Brazil
来源：
EPILEPSIA | 2010年 / 51卷 / 08期
基金：
巴西圣保罗研究基金会;
关键词：
Hippocampus; Chimeric mice; Microglia; Status epilepticus; GFP; CENTRAL-NERVOUS-SYSTEM; NEUROGENESIS; MECHANISMS; MICROGLIA; SEIZURES; EPILEPSY;
D O I：
10.1111/j.1528-1167.2010.02570.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
P>The distribution of bone marrow cells in brain areas during the acute period after pilocarpine-induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP+ bone marrow-derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. The pattern of distribution, proliferation, and differentiation of GFP+ cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.
引用
收藏
页码：1628 / 1632
页数：5
相关论文
共 50 条
  • [31] The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus
    Yeo, S. -I.
    Kim, J. -E.
    Ryu, H. J.
    Seo, C. H.
    Lee, B. C.
    Choi, I. -G.
    Kim, D. -S.
    Kang, T. -C.
    JOURNAL OF NEUROIMMUNOLOGY, 2011, 234 (1-2) : 93 - 102
  • [32] Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus
    Zhu, Shanshan
    Tai, Chao
    Petkau, Terri L.
    Zhang, Si
    Liao, Chengyong
    Dong, Zhifang
    Wen, Wendy
    Chang, Qing
    Wang, Yu Tian
    MacVicar, Brian A.
    Leavitt, Blair R.
    Jia, William
    Cynader, Max S.
    BRAIN RESEARCH, 2013, 1530 : 54 - 65
  • [33] Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus
    Andrioli, Anna
    Fabene, Paolo Francesco
    Mudo, Giuseppa
    Barresi, Vincenza
    Di Liberto, Valentina
    Frinchi, Monica
    Bentivoglio, Marina
    Condorelli, Daniele Filippo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
  • [34] Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus
    Nadam, Jeremie
    Navarro, Fabrice
    Sanchez, Pascal
    Moulin, Colette
    Georges, Beatrice
    Laglaine, Ael
    Pequignot, Jean-Marc
    Morales, Anne
    Ryvlin, Philippe
    Bezin, Laurent
    NEUROBIOLOGY OF DISEASE, 2007, 25 (02) : 412 - 426
  • [35] Time-course changes of hippocalcin expression in the mouse hippocampus following pilocarpine-induced status epilepticus
    Choi, Hee-Soo
    Lee, Choong-Hyun
    JOURNAL OF VETERINARY SCIENCE, 2016, 17 (02) : 137 - 144
  • [36] Phosphorylation of translation initiation factor eIF2α in the brain during pilocarpine-induced status epilepticus in mice
    Carnevalli, LS
    Pereira, CM
    Longo, BM
    Jaqueta, CB
    Avedissian, M
    Mello, LEAM
    Castilho, BA
    NEUROSCIENCE LETTERS, 2004, 357 (03) : 191 - 194
  • [37] Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus
    Zhu, Jing
    Park, Soojin
    Kim, Chul Hoon
    Jeong, Kyoung Hoon
    Kim, Won-Joo
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2023, 248 (08) : 722 - 731
  • [38] Systemic thrombin inhibition ameliorates seizures in a mouse model of pilocarpine-induced status epilepticus
    Lenz, Maximilian
    Ben Shimon, Marina
    Benninger, Felix
    Neufeld, Miri Y.
    Shavit-Stein, Efrat
    Vlachos, Andreas
    Maggio, Nicola
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2019, 97 (11): : 1567 - 1574
  • [39] Effects of ketogenic diets on the occurrence of pilocarpine-induced status epilepticus of rats
    Gama, Iclea Rocha
    Trindade-Filho, Euclides Marinho
    Oliveira, Suzana Lima
    Bueno, Nassib Bezerra
    Melo, Isabelle Tenorio
    Cabral-Junior, Cyro Rego
    Barros, Elenita M.
    Galvao, Jaqueline A.
    Pereira, Wanessa S.
    Ferreira, Raphaela C.
    Domingos, Bruna R.
    Ataide, Terezinha da Rocha
    METABOLIC BRAIN DISEASE, 2015, 30 (01) : 93 - 98
  • [40] The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus
    Cao, Huifang
    Zhang, Lichao
    Qu, Zhenzhen
    Tian, Shuang
    Wang, Zhiyong
    Jiang, Yuhang
    Hou, Qian
    Jia, Lijing
    Wang, Weiping
    BRAIN RESEARCH, 2021, 1764
12345