Transition-metal-free decarboxylation of dimethyl malonate: an efficient construction of α-amino acid esters using TBAI/TBHP

被引：20

作者：

Zhang, Jie ^{[1
]}

Shao, Ying ^{[2
]}

Wang, Yaxiong ^{[1
]}

Li, Huihuang ^{[1
]}

Xu, Dongmei ^{[1
]}

Wan, Xiaobing ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Changzhou Univ, Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 13期

关键词：

IODIDE-CATALYZED SYNTHESIS; OXIDATIVE AMINATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; TERTIARY-AMINES; BETA-KETOACIDS; ALLYLATION; AMIDATION; STRATEGY; BONDS;

D O I：

10.1039/c5ob00109a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition-metal-free decarboxylation coupling process for the preparation of alpha-amino acid esters, which succeeded in merging hydrolysis/decarboxylation/nucleophilic substitution, is well described. This strategy uses commercially available inexpensive starting materials, catalysts and oxidants and has a wide substrate scope and operational simplicity.

引用

页码：3982 / 3987

页数：6

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