The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma

被引：25

作者：

Cipolla, Calogero ^{[1
]}

Cabibi, Daniela ^{[2
]}

Fricano, Salvatore ^{[1
]}

Vieni, Salvatore ^{[1
]}

Gentile, Irene ^{[1
]}

Latteri, Mario Adelfio ^{[1
]}

机构：

[1] Univ Palermo, Dept Oncol, Div Gen & Oncol Surg, AOUP Paolo Giaccone, I-90127 Palermo, Italy

[2] Univ Palermo, Inst Pathol, AOUP Paolo Giaccone, I-90127 Palermo, Italy

来源：

LANGENBECKS ARCHIVES OF SURGERY | 2010年 / 395卷 / 06期

关键词：

Sentinel lymph node; Frozen section; Intraoperative; Breast carcinoma; AXILLARY RECURRENCE RATE; CANCER PATIENTS; IMPRINT CYTOLOGY; BIOPSY; DISSECTION; ACCURACY; LYMPHADENECTOMY; MICROMETASTASES; MULTICENTER; METASTASIS;

D O I：

10.1007/s00423-009-0574-9

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

In breast cancer staging, the need for intraoperative sentinel lymph node (SLN) evaluation has still not been adequately established. This study investigates the impact of intraoperative frozen section (FS) evaluation of SLN to avoid subsequent axillary lymph node dissection (ALND) in patients with positive SLN. A retrospective review of 364 breast cancer patients undergoing SLN biopsy with intraoperative FS evaluation of SLN was performed. Sensitivity and accuracy of FS examination of SLN were 76.4% and 94.2%, respectively. The sensitivity was significantly higher in larger tumors (p < 0.01). No significant correlation was found between FS and histologic type. A second intervention was avoided in 83.9% of the patients with positive SLN. Intraoperative FS examination of the SLN is a useful predictor of axillary lymph node status in breast cancer patients. The majority of SLN-positive patients allows for immediate ALND in a one-stage surgical procedure.

引用

页码：685 / 691

页数：7

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