Modulation of D-serine levels in brains of mice lacking PICK1

被引：40

作者：

Hikida, Takatoshi ^{[1
]}

Mustafa, Asif K. ^{[1
]}

Maeda, Kazuhisa ^{[2
]}

Fujii, Kumiko ^{[2
]}

Barrow, Roxanne K. ^{[1
]}

Saleh, Masoumeh ^{[1
]}

Huganir, Richard L. ^{[1
]}

Snyder, Solomon H. ^{[1
,2
]}

Hashimoto, Kenji ^{[3
]}

Sawa, Akira ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA

[3] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba, Japan

来源：

BIOLOGICAL PSYCHIATRY | 2008年 / 63卷 / 10期

关键词：

bipolar disorder; D-serine; knockout mice; PICK1; schizophrenia; serine racemase;

D O I：

10.1016/j.biopsych.2007.09.025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: D-serine is an endogenous coagonist of the N-methyl-D-aspartate subtype glutamate receptor. Genetic association studies have implicated genes coding for enzymes associated with D-serine metabolism in schizophrenia and bipolar disorder. Methods: Protein expression of serine racemase (SR) and its binding partner, protein interacting with C-kinase (PICK1), were examined by Western blotting in brains from wildtype and PICK1 knockout mice. Levels of D-serine in wildtype and PICK1 mice were also examined by an established high-pressure liquid chromatography protocol. Results: Expression of SR and PICK1 proteins was developmentally regulated. Although no change was observed in the level of SR protein, levels of D-serine were selectively decreased in the forebrain of neonatal PICK1 knockout mice, compared with those in wildtype mice. Conclusions: PICK1 may be involved in the regulation of brain D-serine levels and SR in a spatially and temporally specific manner.

引用

页码：997 / 1000

页数：4

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