Modulation of D-serine levels in brains of mice lacking PICK1

被引：40
作者：
Hikida, Takatoshi [1 ]
Mustafa, Asif K. [1 ]
Maeda, Kazuhisa [2 ]
Fujii, Kumiko [2 ]
Barrow, Roxanne K. [1 ]
Saleh, Masoumeh [1 ]
Huganir, Richard L. [1 ]
Snyder, Solomon H. [1 ,2 ]
Hashimoto, Kenji [3 ]
Sawa, Akira [1 ,2 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA
[3] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba, Japan
来源：
BIOLOGICAL PSYCHIATRY | 2008年 / 63卷 / 10期
关键词：
bipolar disorder; D-serine; knockout mice; PICK1; schizophrenia; serine racemase;
D O I：
10.1016/j.biopsych.2007.09.025
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Background: D-serine is an endogenous coagonist of the N-methyl-D-aspartate subtype glutamate receptor. Genetic association studies have implicated genes coding for enzymes associated with D-serine metabolism in schizophrenia and bipolar disorder. Methods: Protein expression of serine racemase (SR) and its binding partner, protein interacting with C-kinase (PICK1), were examined by Western blotting in brains from wildtype and PICK1 knockout mice. Levels of D-serine in wildtype and PICK1 mice were also examined by an established high-pressure liquid chromatography protocol. Results: Expression of SR and PICK1 proteins was developmentally regulated. Although no change was observed in the level of SR protein, levels of D-serine were selectively decreased in the forebrain of neonatal PICK1 knockout mice, compared with those in wildtype mice. Conclusions: PICK1 may be involved in the regulation of brain D-serine levels and SR in a spatially and temporally specific manner.
引用
收藏
页码：997 / 1000
页数：4
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