The Role of Ferroptosis in Cancer Development and Treatment Response

被引：342

作者：

Lu, Bin ^{[1
]}

Chen, Xiao Bing ^{[1
]}

Ying, Mei Dan ^{[1
]}

He, Qiao Jun ^{[1
]}

Cao, Ji ^{[1
]}

Yang, Bo ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou, Zhejiang, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2018年 / 8卷

基金：

中国国家自然科学基金;

关键词：

ferroptosis; lipid ROS; iron metabolism; cancer therapeutics; tumorigenesis; HEPATOCELLULAR-CARCINOMA CELLS; CHEMOTHERAPY RESISTANCE; BREAST-CANCER; CYCLE ARREST; CYSTINE/GLUTAMATE ANTIPORTER; THERAPEUTIC OPPORTUNITIES; 5-LIPOXYGENASE INHIBITOR; TUMOR SUPPRESSION; OXIDATIVE DAMAGE; DEATH;

D O I：

10.3389/fphar.2017.00992

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ferroptosis is a process driven by accumulated iron-dependent lipid ROS that leads to cell death, which is a distinct regulated cell death comparing to other cell death. The lethal metabolic imbalance resulted from GSH depletion or inactivation of glutathione peroxidase 4 is the executor of ferroptosis within the cancer cell. Small molecules-induced ferroptosis has a strong inhibition of tumor growth and enhances the sensitivity of chemotherapeutic drugs, especially in the condition of drug resistance. These evidences have highlighted the importance of ferroptosis in cancer therapeutics, but the roles of ferroptosis in tumorigenesis and development remain unclear. This article provides an overview of the mechanisms of ferroptosis, highlights the role of ferroptosis in cancer and discusses strategies for therapeutic modulation.

引用

页数：8

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