Prevalence and factors associated with osteoporosis and fragility fractures in patients with primary Sjogren syndrome

被引：6

作者：

Carlos Salman-Monte, Tarek ^{[1
]}

Sanchez-Piedra, Carlos ^{[2
]}

Fernandez Castro, Monica ^{[3
]}

Luis Andreu, Jose ^{[3
]}

Martinez Taboada, Victor ^{[4
]}

Olive, Alejandro ^{[5
]}

Rosas, Jose ^{[6
]}

Menor, Raul ^{[7
]}

Rodriguez, Beatriz ^{[8
]}

Garcia Aparicio, Angel ^{[9
]}

Lopez Longo, Francisco Javier ^{[10
]}

Manrique-Arija, Sara ^{[11
]}

Garcia Vadillo, Jesus Alberto ^{[12
]}

Gil Barato, Susana ^{[13
]}

Lopez-Gonzalez, Ruth ^{[14
]}

Galisteo, Carlos ^{[15
]}

Gonzalez Martin, Jorge ^{[16
]}

Ruiz Lucea, Esther ^{[17
]}

Erausquin, Celia ^{[18
]}

Melchor, Sheila ^{[19
]}

Moreira, Begona ^{[20
]}

Raya, Enrique ^{[21
]}

Maria Pego-Reigosa, Jose ^{[22
]}

Cid, Natalia ^{[23
]}

Judez, Enrique ^{[24
]}

Moriano, Clara ^{[25
]}

Javier Narvaez, Francisco ^{[26
]}

Corominas, Hector ^{[27
]}

Garcia Magallon, Blanca ^{[28
]}

Guillen Astete, Carlos ^{[29
]}

Castellvi, Ivan ^{[30
]}

Bohorquez, Cristina ^{[31
]}

Loricera, Javier ^{[4
]}

Belzunegui, Joaquin ^{[32
]}

Illera, Oscar ^{[33
]}

Torrente-Segarra, Vicenc ^{[34
]}

机构：

[1] Hosp del Mar Parc Salut Mar IMIM, Rheumatol Dept, Passeig Maritim 25-29, Barcelona 08005, Spain

[2] Unidad Invest SER, Madrid, Spain

[3] Hosp Puerta de Hierro, Rheumatol Dept, Madrid, Spain

[4] Hosp Marques de Valdecilla, Rheumatol Dept, Santander, Spain

[5] Hosp Badalona Germans Trias & Pujol, Rheumatol Dept, Barcelona, Spain

[6] Hosp Marina Baixa, Rheumatol Dept, Alicante, Spain

[7] Hosp Gen Jerez de la Frontera, Rheumatol Dept, Madrid, Spain

[8] Hosp Univ Canarias, Rheumatol Dept, Santa Cruz De Tenerife, Spain

[9] Hosp Virgen de la Salud, Rheumatol Dept, Toledo, Spain

[10] Hosp Gregorio Maranon, Rheumatol Dept, Madrid, Spain

[11] Hosp Carlos Haya, Rheumatol Dept, Malaga, Spain

[12] Hosp Princesa, Rheumatol Dept, Madrid, Spain

[13] Hosp Gen Alicante, Rheumatol Dept, Alicante, Spain

[14] Hosp Virgen de la Concha, Rheumatol Dept, Zamora, Spain

[15] Rheumatol Dept, Hosp Parc Tauli, Sabadell, Spain

[16] Hosp Madrid Norte Sanchinarro, Rheumatol Dept, Madrid, Spain

[17] Hosp Basurto, Rheumatol Dept, Vizcaya, Spain

[18] Hosp Gran Canaria Doctor Negrin, Rheumatol Dept, Las Palmas Gran Canaria, Spain

[19] Hosp Doce Octubre, Rheumatol Dept, Madrid, Spain

[20] Complejo Hosp Pontevedra, Rheumatol Dept, Pontevedra, Spain

[21] Hosp Clin San Cecilio, Rheumatol Dept, Granada, Spain

[22] Hosp Univ Vigo, Rheumatol Dept, Galicia Hlth Res, IRIDIS VIGO Grp, Vigo, Spain

[23] Hosp Valme, Rheumatol Dept, Seville, Spain

[24] Hosp Albacete, Rheumatol Dept, Albacete, Spain

[25] Hosp Leon, Rheumatol Dept, Leon, Spain

[26] Hosp Bellvitge Princeps Espanya, Rheumatol Dept, Barcelona, Spain

[27] Hosp St Joan Despi Moises Broggi, Rheumatol Dept, Barcelona, Spain

[28] Hosp Miguel Servet, Rheumatol Dept, Zaragoza, Spain

[29] Hosp Ramon & Cajal, Rheumatol Dept, Madrid, Spain

[30] Hosp San Pau & Santa Creu, Rheumatol Dept, Barcelona, Spain

[31] Hosp Principe Asturias, Rheumatol Dept, Alcala De Henares, Spain

[32] Hosp Donostia, Rheumatol Dept, Donostia San Sebastian, Spain

[33] Hosp Infanta Sofia, Rheumatol Dept, Madrid, Spain

[34] Hosp Comarcal Alt Penedes, Rheumatol Dept, Vilafranca Del Penedes, Spain

来源：

RHEUMATOLOGY INTERNATIONAL | 2020年 / 40卷 / 08期

关键词：

Sjogren syndrome; Osteoporosis; Osteoporotic fractures; Bone remodeling; BONE-MINERAL DENSITY; RENAL TUBULAR-ACIDOSIS; FANCONIS-SYNDROME; VITAMIN-D; WOMEN;

D O I：

10.1007/s00296-020-04615-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study aimed at determining socio-demographic and clinical factors of primary Sjogren syndrome (pSS) associated with osteoporosis (OP) and fragility fracture. SJOGRENSER is a cross-sectional study of patients with pSS, classified according to American European consensus criteria developed in 33 Spanish rheumatology departments. Epidemiological, clinical, serological and treatment data were collected and a descriptive analysis was conducted. Bivariate and multivariate analyses were performed using a binomial logistic regression to study the factors associated with OP and fragility fracture in pSS. 437 patients were included (95% women, with a median age of 58.6 years). 300 women were menopausal (76.4%). Prevalence of OP was 18.5% [in men (N = 21) this measured 19%]. A total of 37 fragility fractures were recorded. In the multivariate analysis, there was an association between OP and age: in the 51-64 age range (menopausal women), the OR measured 9.993 (95% CI 2301-43,399,p = 0.002); In the age > 64 years group, OR was 20.610 (4.679-90.774,p < 0.001); between OP and disease duration, OR was 1.046 (1.008-1085,p = 0.017); past treatment with corticosteroids, OR 2.548 (1.271-5.105,p = 0.008). Similarly, an association was found between fragility fractures and age: in the 51-64 age group, OR measured 5.068 (1.117-22,995,p = 0.035), age > 64 years, OR was 7.674 (1.675-35,151,p < 0.009); disease duration, OR 1.049 (CI 1.003-1097,p < 0.036) and the ESSDAI index, OR 1.080 (1.029-1134,p = 0.002). Patients with pSS can develop osteoporosis and fragility fractures over the course of the disease. Age, corticosteroids treatment and disease duration were associated with the development of OP. Disease duration and ESSDAI were associated with the development of fractures in patients with pSS.

引用

页码：1259 / 1265

页数：7

共 32 条

[1] Osteoporosis in Rheumatic Diseases [J].

Adami, Giovanni ;

Fassio, Angelo ;

Rossini, Maurizio ;

Caimmi, Cristian ;

Giollo, Alessandro ;

Orsolini, Giovanni ;

Viapiana, Ombretta ;

Gatti, Davide .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (23)

[2] Vitamin D in "early" primary Sjogren's syndrome: does it play a role in influencing disease phenotypes? [J].

Baldini, Chiara ;

Delle Sedie, Andrea ;

Luciano, Nicoletta ;

Pepe, Pasquale ;

Ferro, Francesco ;

Talarico, Rosaria ;

Tani, Chiara ;

Mosca, Marta .

RHEUMATOLOGY INTERNATIONAL, 2014, 34 (08) :1159-1164

[3] Bone mineral density in women with systemic lupus erythematosus [J].

Bhattoa, HP ;

Bettembuk, P ;

Balogh, A ;

Szegedi, G ;

Kiss, E .

CLINICAL RHEUMATOLOGY, 2002, 21 (02) :135-141

[4] Elderly onset of primary Sjogren's syndrome: Clinical manifestations, serological features and oral/ocular diagnostic tests. Comparison with adult and young onset of the disease in a cohort of 336 Italian patients [J].

Botsios, Costantino ;

Furlan, Antonio ;

Ostuni, Pierantonio ;

Sfriso, Paolo ;

Andretta, Marilisa ;

Ometto, Francesca ;

Raffeiner, Bernd ;

Todesco, Silvano ;

Punzi, Leonardo .

JOINT BONE SPINE, 2011, 78 (02) :171-174

[5] Primary Sjogren's syndrome [J].

Bowman, S. J. .

LUPUS, 2018, 27 :32-35

[6]

Buckley LM, 2000, CLIN EXP RHEUMATOL, V18, pS41

[7]

Favus MJ, 2006, PRIMER METABOLIC BON, P339

[8] Sjogren SER: National registry of the Spanish Society of Rheumatology of patients with primary Sjogren syndrome: Objectives and methodology [J].

Fernandez Castro, Monica ;

Luis Andreu, Jose ;

Sanchez-Piedra, Carlos ;

Martinez Taboada, Victor ;

Olive, Alejandro ;

Rosas, Jose ;

Sanchez-Alonso, Fernando .

REUMATOLOGIA CLINICA, 2016, 12 (04) :184-189

[9] Tubulointerstitial nephritis-induced hypophosphatemic osteomalacia in Sjogren's syndrome: a case report and review of the literature [J].

Geng, Yan ;

Zhao, Youlu ;

Zhang, Zhuoli .

CLINICAL RHEUMATOLOGY, 2018, 37 (01) :257-263

[10] Subclinical atherosclerosis and impaired bone health in patients with primary Sjogren's syndrome: prevalence, clinical and laboratory associations [J].

Gravani, Fotini ;

Papadaki, Ioanna ;

Antypa, Eleni ;

Nezos, Andrianos ;

Masselou, Kyriaki ;

Ioakeimidis, Dimitrios ;

Koutsilieris, Michael ;

Moutsopoulos, Haralampos M. ;

Mavragani, Clio P. .

ARTHRITIS RESEARCH & THERAPY, 2015, 17

← 1 2 3 4 →