Microbiota, alcohol and liver

被引：0

作者：

Gerard, Philippe ^{[1
,2
]}

机构：

[1] INRA, Micalis UMR1319, Jouy En Josas, France

[2] AgroParisTech, UMR Micalis, Jouy En Josas, France

来源：

CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION | 2015年 / 19卷 / 5-6期

关键词：

Gut microbiota; Alcoholic liver disease; Gut barrier; Probiotics; DISEASE; ENDOTOXEMIA; ETHANOL; INJURY; PROBIOTICS; CIRRHOSIS; SEVERITY; BARRIER; FLORA; MICE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alcoholic liver disease can be divided into overlapping phases with distinct pathological and clinical features. The severe stages, including acute steatohepatitis and cirrhosis, are associated with a high mortality risk. Alcohol consumption together with gut microbiota activity increase gut permeability, leading to the passage of bacterial components which may trigger liver inflammation. Alcohol consumption is thought to change gut microbiota composition. However, only a fraction of alcoholic patients display a dysbiosis, associated with increased gut permeability. Probiotic treatments have been proven to reduce alcohol-induced liver injury in animal models and in humans.

引用

页码：142 / 144

页数：3

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