Drug repurposing-A search for novel therapy for the treatment of diabetic neuropathy

被引：13

作者：

Paul, Arpita ^{[1
]}

Kumar, Mohit ^{[1
,2
]}

Das, Parikshit ^{[1
,2
]}

Guha, Nilayan ^{[1
]}

Rudrapal, Mithun ^{[1
,3
]}

Zaman, Md. Kamaruz

机构：

[1] Dibrugarh Univ, Fac Sci & Engn, Dept Pharmaceut Sci, Dibrugarh 786004, Assam, India

[2] Def Res Lab, Div Pharmaceut Technol, Tezpur 784001, Assam, India

[3] Rasiklal M Dhariwal Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Pune 411019, Maharashtra, India

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 156卷

关键词：

Diabetic neuropathy; Drug repurposing; Molecular mechanisms; Oxidative stress; Neuro-inflammation; ACTIVATED PROTEIN-KINASE; PRIMARY SENSORY NEURONS; GLYCATION END-PRODUCTS; SPINAL NERVE LIGATION; POLY(ADP-RIBOSE) POLYMERASE ACTIVATION; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; PERIPHERAL NEUROPATHY; DOUBLE-BLIND; ENDOTHELIAL DYSFUNCTION;

D O I：

10.1016/j.biopha.2022.113846

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Diabetic neuropathy is a chronic complication to metabolic disorder, diabetes mellitus. Till date, diagnosis and treatment of diabetic neuropathy remain elusive with challenges associated with the efficacy and safety of the current therapeutics. Considering, the hurdles associated with discovery of de novo drugs, repurposing of old drugs for new therapeutic modalities sounds promising. This review, focuses on a molecular pathways involved in the progression of diabetic neuropathy, and the current pharmacological and non-pharmacological therapies implemented. Furthermore, a holistic and mechanism centric drug repurposing approach is pursued for identi-fication of existing drugs as novel therapy in the treatment of diabetic neuropathy. The global status of ongoing clinical research on diabetic neuropathy is also highlighted. In conclusion, the barriers associated with drug repurposing is identified to stimulate the curiosity of the researchers to overcome them and rapidly translate the drugs to the patients suffering from diabetic neuropathy.

引用

页数：13

共 184 条

[1] A critical review of the capsaicin 8% patch for the treatment of neuropathic pain associated with diabetic peripheral neuropathy of the feet in adults [J].