Alpha-1-adrenergic receptors: Targets for agonist drugs to treat heart failure

被引：102
作者：
Jensen, Brian C. [1 ,3 ,4 ]
O'Connell, Timothy D. [5 ]
Simpson, Paul C. [1 ,2 ,3 ]
机构：
[1] VA Med Ctr, Div Cardiol, San Francisco, CA USA
[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA
[4] Univ N Carolina, Div Cardiol, Chapel Hill, NC 27599 USA
[5] Sanford Res Univ S Dakota, Cardiovasc Hlth Res Ctr, Sioux Falls, SD 57104 USA
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2011年 / 51卷 / 04期
关键词：
alpha-1-Adrenergic receptors; Cardiac myocytes; Heart failure; Drug development; PROTEIN-KINASE-C; INDUCED CARDIAC-HYPERTROPHY; ACTIVE ALPHA(1B)-ADRENERGIC RECEPTORS; ALPHA-ADRENOCEPTOR STIMULATION; LIPID-LOWERING TREATMENT; RAT MYOCARDIAL-CELLS; FAILING HUMAN-HEART; SUSTAINED-RELEASE MOXONIDINE; HUMAN VENTRICULAR MYOCARDIUM; ARTERIAL BLOOD-PRESSURE;
D O I：
10.1016/j.yjmcc.2010.11.014
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Evidence from cell, animal, and human studies demonstrates that alpha 1-adrenergic receptors mediate adaptive and protective effects in the heart. These effects may be particularly important in chronic heart failure, when catecholamine levels are elevated and beta-adrenergic receptors are down-regulated and dysfunctional. This review summarizes these data and proposes that selectively activating alpha 1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure." Published by Elsevier Ltd.
引用
收藏
页码：518 / 528
页数：11
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