MicroRNA-129-5p inhibits the proliferation and migration in renal cell carcinoma via targeting IGF2BP1

被引：0

作者：

Xu, Hai-Liang ^{[1
]}

Feng, Yun-Yun ^{[2
]}

Jia, Zhan-Kui ^{[3
]}

Zhang, Yong-Gang ^{[4
]}

Li, Jun ^{[1
]}

Xia, Ming-Liang ^{[1
]}

机构：

[1] Zhumadian Cent Hosp, Dept Urol Surg, Zhumadian 463000, Peoples R China

[2] Zhumadian Cent Hosp, Dept Pediat, Zhumadian 463000, Peoples R China

[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Urol Surg, Zhengzhou 450000, Peoples R China

[4] Zhumadian Cent Hosp, Dept Emergency, Zhumadian 463000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2016年 / 9卷 / 08期

关键词：

miR-129-5p; renal cell carcinoma; IGF2BP1; HEPATOCELLULAR-CARCINOMA; TUMOR-SUPPRESSOR; FEEDBACK LOOP; CANCER; EXPRESSION; METASTASIS; MIR-129-5P;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been suggested to play an essential role in tumorigenesis. Accumulating evidences indicated that miR-129-5p could function as a tumor suppressor in some malignancies. However, its role and mechanism in renal cell carcinoma (RCC) remains unclear. Here, we found that miR-129-5p was significantly decreased in ccRCC tissues and cell lines. Ectopic overexpression of miR-129-5p remarkably suppressed RCC cell proliferation, migration, and invasion. IGF2BP1 was identified as a target of miR-129-5p in RCC cells. Furthermore, down-regulation of IGF2BP1 by siRNA performed similar effects with overexpression of miR-129-5p in RCC cells. Collectively, our findings indicate that miR-129-5p may suppress renal cancer cell growth and motility partially by targeting IGF2BP1.

引用

页码：8254 / 8260

页数：7

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