Clinical and epidemiological features of 123 cases of cryptococcosis in MATO Grosso Do Sul, Brazil

被引:33
作者
Campos Lindenberg, Andrea de Siqueira [1 ]
Chang, Marilene Rodrigues [2 ]
Miranda Paniago, Anamaria Melo [3 ]
Lazera, Marcia dos Santos [4 ]
Frank Moncada, Paula Maria [2 ]
Bonfim, Gisele Facholi [2 ]
Nogueira, Susie Andries [5 ]
Wanke, Bodo [4 ]
机构
[1] Univ Desenvolvimento Estado & Regiao Pantanal, Program Med, Campo Grande, MS, Brazil
[2] Univ Fed Mato Grosso do Sul, Dept Biochem & Pharm, Campo Grande, MS, Brazil
[3] Univ Fed Mato Grosso do Sul, Dept Clin Med, Campo Grande, MS, Brazil
[4] Inst Pesquisa Clin Evandro Chagas, Mycol Serv, FIOCRUZ, Rio De Janeiro, Brazil
[5] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Infect Dis Serv, Rio de Janeiro, Brazil
来源
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO | 2008年 / 50卷 / 02期
关键词
epidemiology; cryptococcosis; Brazil; cryptococcus gattii; cryptococcus neoformans;
D O I
10.1590/S0036-46652008000200002
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
To identify the clinical and epidemiological profile of cryptococcosis diagnosed at the University Hospital of the Federal University of Mato Grosso do Sul, Brazil. medical records of 123 patients admitted from January 1995 to December 2005 were analyzed. One hundred and four cases (84.5%) had HIV infection, six (4.9%) had other predisposing conditions and 13 (10.6%) were immunocompetent. Male patients predominated (68.3%) and their age ranged from 19 to 69 years (mean: 35.9). Most patients (73.2%) were born and lived lifelong in the state of Mato Grosso do Sul. Involvement of the central nervous system occurred in 103 patients (83.7%) and headache and vomiting were the most frequent symptoms. In 77 cases it was possible to identify the Cryptococcus species: 69 (89.6%) C. neoformans and eight (10.4%) C. gattii. Amphotericin B was the drug of choice for treatment (106/123), followed by fluconazole in 60% of cases. The overall lethality rate was 49.6%, being 51% among the HIV infected patients and 41.2% among the non-HIV infected (p > 0.05). Although cryptococcosis exhibited in our region a similar behavior to that described in the literature, the detection of an important rate of immunocompetent individuals and five C gattii cryptococcosis in HIV-infected patients is noteworthy.
引用
收藏
页码:75 / 78
页数:4
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