Multi-omics signatures of the human early life exposome

被引：67

作者：

Maitre, Lea ^{[1
,2
,3
]}

Bustamante, Mariona ^{[1
,2
,3
,4
]}

Hernandez-Ferrer, Carles ^{[1
,2
,3
]}

Thiel, Denise ^{[5
]}

Lau, Chung-Ho E. ^{[6
,7
]}

Siskos, Alexandros ^{[8
]}

Vives-Usano, Marta ^{[1
,2
,3
,4
]}

Ruiz-Arenas, Carlos ^{[1
,2
,3
]}

Pelegri-Siso, Dolors ^{[1
,2
,3
]}

Robinson, Oliver ^{[6
]}

Mason, Dan ^{[9
]}

Wright, John ^{[9
]}

Cadiou, Solene ^{[10
]}

Slama, Remy ^{[10
]}

Heude, Barbara ^{[11
]}

Casas, Maribel ^{[1
,2
,3
]}

Sunyer, Jordi ^{[1
,2
,3
,12
]}

Papadopoulou, Eleni Z. ^{[13
]}

Gutzkow, Kristine B. ^{[13
]}

Andrusaityte, Sandra ^{[14
]}

Grazuleviciene, Regina ^{[14
]}

Vafeiadi, Marina ^{[15
]}

Chatzi, Leda ^{[16
]}

Sakhi, Amrit K. ^{[13
]}

Thomsen, Cathrine ^{[13
]}

Tamayo, Ibon ^{[17
]}

Nieuwenhuijsen, Mark ^{[1
,2
,3
]}

Urquiza, Jose ^{[1
,2
,3
]}

Borras, Eva ^{[2
,4
]}

Sabido, Eduard ^{[2
,4
]}

Quintela, Ines ^{[18
]}

Carracedo, Angel ^{[18
,19
]}

Estivill, Xavier ^{[4
]}

Coen, Muireann ^{[7
,20
]}

Gonzalez, Juan R. ^{[1
,2
,3
]}

Keun, Hector C. ^{[7
,8
]}

Vrijheid, Martine ^{[1
,2
,3
]}

机构：

[1] Inst Global Hlth ISGlobal, Barcelona, Spain

[2] Univ Pompeu Fabra UPF, Barcelona, Spain

[3] Consorcio Invest Biomed Red Epidemiol & Salud Pub, Madrid, Spain

[4] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain

[5] Imperial Coll London, Dept Math, London, England

[6] Imperial Coll London, MRC Ctr Environm & Hlth, Sch Publ Hlth, London, England

[7] Imperial Coll London, Dept Metab Digest & Reprod, Div Syst Med, London, England

[8] Imperial Coll London, Dept Surg & Canc, Div Canc, Canc Metab & Syst Toxicol Grp, London, England

[9] Bradford Teaching Hosp NHS Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England

[10] Univ Grenoble Alpes, Inst Adv Biosci IAB, CNRS, INSERM,Team Environm Epidemiol Appl Reprod & Resp, Grenoble, France

[11] Univ Paris, Ctr Res Epidemiol & Stat CRESS, INSERM, Paris, France

[12] Hosp Mar Med Res Inst IMIM, Barcelona, Spain

[13] Norwegian Inst Publ Hlth, Div Climate & Environm Hlth, Oslo, Norway

[14] Vytautas Magnus Univ, Dept Environm Sci, Kaunas, Lithuania

[15] Univ Crete, Fac Med, Dept Social Med, Iraklion, Greece

[16] Univ Southern Calif, Dept Populat & Publ Hlth Sci, Los Angeles, CA 90007 USA

[17] Univ Navarra, Computat Biol Program, CIMA, Pamplona, Spain

[18] Univ Santiago de Compostela, Ctr Invest Biomed Red Enfermedades Raras CIBERER, CIMUS, Med Genom Grp, Santiago De Compostela, Spain

[19] Galician Fdn Genom Med, Inst Invest Sanitaria Santiago Compostela IDIS, Serv Gallego Salud SERGAS, Santiago De Compostela, Galicia, Spain

[20] AstraZeneca, R&D, Oncol Safety Clin Pharmacol & Safety Sci, Cambridge, England

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金; 欧盟第七框架计划;

关键词：

CARDIOVASCULAR RISK-FACTORS; TRIMETHYLAMINE N-OXIDE; COHORT PROFILE; MATERNAL SMOKING; CHILDHOOD OBESITY; DNA METHYLATION; BLOOD-PRESSURE; EXPOSURE; HEALTH; METABOLOMICS;

D O I：

10.1038/s41467-022-34422-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations (https://helixomics.isglobal.org/) will serve to guide future investigation into the biological imprints of the early life exposome.

引用

页数：18

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