Successful Treatment of a Severe Vision-Threatening Paradoxical Tuberculous Reaction with Infliximab First Pediatric Use

被引：14

作者：

Abo, Yara-Natalie ^{[1
]}

Curtis, Nigel ^{[1
,2
,3
]}

Butters, Coen ^{[1
]}

Rozen, Thomas H. ^{[1
,2
,3
]}

Marais, Ben J. ^{[4
,5
]}

Gwee, Amanda ^{[1
,2
,3
]}

机构：

[1] Royal Childrens Hosp Melbourne, Infect Dis Unit, 50 Flemington Rd, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[3] Murdoch Childrens Res Inst, Infect Dis Grp, Parkville, Vic, Australia

[4] Childrens Hosp, Infect Dis Unit, Westmead, NSW, Australia

[5] Univ Sydney, Sydney, NSW, Australia

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2020年 / 39卷 / 04期

关键词：

tuberculous meningitis; tuberculosis; paradoxical reaction; optochiasmatic arachnoiditis; infliximab; thalidomide; ADJUNCTIVE THALIDOMIDE THERAPY; MENINGITIS; CHILDREN; CORTICOSTEROIDS; PREDICTORS;

D O I：

10.1097/INF.0000000000002578

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 7-year-old girl with tuberculous (TB) meningitis developed optochiasmatic arachnoiditis, a vision-threatening paradoxical reaction, after starting TB treatment including adjunctive steroid therapy. She was treated with infliximab with complete recovery. This is the first report of the use of a tissue necrosis factor alpha inhibitor for the treatment of a severe paradoxical TB reaction in a child.

引用

收藏

页码：E42 / E45

页数：4

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