Successful Treatment of a Severe Vision-Threatening Paradoxical Tuberculous Reaction with Infliximab First Pediatric Use

被引：14
作者：
Abo, Yara-Natalie [1 ]
Curtis, Nigel [1 ,2 ,3 ]
Butters, Coen [1 ]
Rozen, Thomas H. [1 ,2 ,3 ]
Marais, Ben J. [4 ,5 ]
Gwee, Amanda [1 ,2 ,3 ]
机构：
[1] Royal Childrens Hosp Melbourne, Infect Dis Unit, 50 Flemington Rd, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
[3] Murdoch Childrens Res Inst, Infect Dis Grp, Parkville, Vic, Australia
[4] Childrens Hosp, Infect Dis Unit, Westmead, NSW, Australia
[5] Univ Sydney, Sydney, NSW, Australia
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2020年 / 39卷 / 04期
关键词：
tuberculous meningitis; tuberculosis; paradoxical reaction; optochiasmatic arachnoiditis; infliximab; thalidomide; ADJUNCTIVE THALIDOMIDE THERAPY; MENINGITIS; CHILDREN; CORTICOSTEROIDS; PREDICTORS;
D O I：
10.1097/INF.0000000000002578
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A 7-year-old girl with tuberculous (TB) meningitis developed optochiasmatic arachnoiditis, a vision-threatening paradoxical reaction, after starting TB treatment including adjunctive steroid therapy. She was treated with infliximab with complete recovery. This is the first report of the use of a tissue necrosis factor alpha inhibitor for the treatment of a severe paradoxical TB reaction in a child.
引用
收藏
页码：E42 / E45
页数：4
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