Investigation into the Combination of Aspirin with Non-steroidal Anti-inflammatory Drugs

被引：0

作者：

Ito, Naoko ^{[1
]}

Yokoyama, Haruko ^{[1
]}

Soeda, Shinji ^{[2
]}

Suzuki, Yuji ^{[3
]}

Ikeda, Noriyuki ^{[4
]}

Tokuoka, Kentaro ^{[5
]}

Watanabe, Masayuki ^{[3
]}

Kitagawa, Yasuhisa ^{[5
]}

Yamada, Yasuhiko ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Dept Clin Evaluat Drug Efficacy, Tokyo 1920392, Japan

[2] Tokai Univ Hosp, Dept Pharm, Kanagawa 2591193, Japan

[3] Tokai Univ Hachioji Hosp, Dept Pharm, Tokyo 1920032, Japan

[4] Tokai Univ Hachioji Hosp, Cent Clin Lab, Tokyo 1920032, Japan

[5] Tokai Univ Hachioji Hosp, Dept Neurol, Tokyo 1920032, Japan

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2011年 / 131卷 / 07期

关键词：

antiplatelet effect; aspirin; ibuprofen; drug interaction; INHIBITORS; CYCLOOXYGENASE; IBUPROFEN;

D O I：

10.1248/yakushi.131.1073

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has been reported that non-steroidal anti-inflammatory drugs (NSAIDs) interact with aspirin to influence its antiplatelet effect. For example, there have been reported that the rate of platelet aggregation inhibition associated with aspirin was significantly decreased when ibuprofen was taken before administration of aspirin, as compared with aspirin alone. In this study, we investigated the prescriptions on combination of aspirin with NSAIDs. The subjects were consisted of 1212 patients who were prescribed aspirin in March, 2008 in Tokai University Hachioji Hospital. The patients prescribed combination of aspirin with NSAIDs were 8.1% and 18.6% of those were prescribed in the order of adminstration to induce drug interaction. The pharmacists should provide information about drug interactions of aspirin with NSAIDs to the doctors and patients, and it is necessary to pay attention of these interactions.

引用

页码：1073 / 1077

页数：5

共 11 条

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