Fruit and vegetable consumption and breast cancer incidence: Repeated measures over 30 years of follow-up

被引:100
作者
Farvid, Maryam S. [1 ]
Chen, Wendy Y. [2 ,3 ,4 ]
Rosner, Bernard A. [2 ,3 ]
Tamimi, Rulla M. [2 ,3 ,5 ]
Willett, Walter C. [1 ,2 ,3 ,5 ]
Eliassen, A. Heather [2 ,3 ,5 ]
机构
[1] Harvard TH Chan Sch Publ Hlth, Dept Nutr, 655 Huntington Ave,SPH 2,Level 3, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA
[3] Harvard Med Sch, Boston, MA USA
[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[5] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
fruit and vegetable; breast cancer; estrogen receptor; molecular subtype; PROGESTERONE-RECEPTOR STATUS; ESTROGEN-RECEPTOR; POOLED ANALYSIS; DIETARY CAROTENOIDS; BETA-CAROTENE; VITAMIN-C; RISK; FIBER; METAANALYSIS; PATTERNS;
D O I
10.1002/ijc.31653
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We evaluated the relation of fruit and vegetable consumption, including specific fruits and vegetables, with incident breast cancer characterized by menopausal status, hormone receptor status and molecular subtypes. Fruit and vegetable consumption, cumulatively averaged across repeated, validated questionnaires, was examined in relation to risk of invasive breast cancer among 182,145 women initially aged 27-59 years in the Nurses' Health Study (NHS, 1980-2012) and NHSII (1991-2013). Cox proportional hazards regression, adjusted for known risk factors, was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) and assessed tumors by hormone receptor status and molecular subtypes. We prospectively documented 10,911 invasive breast cancer cases. Greater intake of total fruits and vegetables, especially cruciferous and yellow/orange vegetables, was associated with significantly lower breast cancer risk (>5.5 vs. <= 2.5 servings/day HR = 0.89, 95% CI = 0.83-0.96; p(trend) = 0.006). Intake of total vegetables was especially associated with lower risk of estrogen receptor negative tumors (HR per 2 additional servings/day as a continuous variable = 0.84, 95%CI = 0.77-0.93; p(heterogeneity) = 0.02). Among molecular subtypes, higher intake of total fruits and vegetables (HR per 2 additional servings/day as a continuous variable) was most strongly associated with lower risk of human epidermal growth factor receptor 2 (HER2)-enriched (HR = 0.79, 95%CI = 0.67-0.93), basal-like (HR = 0.84, 95%CI = 0.72-0.97) and luminal A (HR = 0.94, 95%CI = 0.89-0.99), but not with luminal B tumors (p(heterogeneity) = 0.03). In conclusion, our findings support that higher intake of fruits and vegetables, and specifically cruciferous and yellow/orange vegetables, may reduce the risk of breast cancer, especially those that are more likely to be aggressive tumors.
引用
收藏
页码:1496 / 1510
页数:15
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