Bone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival

被引：0

作者：

Guillem, Vicent ^{[1
]}

Calabuig, Marisa ^{[1
]}

Brunet, Salut ^{[2
,3
]}

Esteve, Jordi ^{[4
]}

Escoda, Lourdes ^{[5
]}

Gallardo, David ^{[6
]}

Ribera, Josep-Maria ^{[7
]}

Queipo de Llano, Maria Paz ^{[8
]}

Arnan, Montserrat ^{[9
]}

Pedro, Carme ^{[10
]}

Luz Amigo, Maria ^{[11
]}

Marti-Tutusaus, Josep M. ^{[12
]}

Garcia-Guinon, Antoni ^{[13
]}

Bargay, Joan ^{[14
]}

Sampol, Antonia ^{[15
]}

Salamero, Olga ^{[16
]}

Font, Llorenc ^{[17
]}

Talarn, Carme ^{[4
]}

Hoyos, Montserrat ^{[2
,3
]}

Diaz-Beya, Marina ^{[4
]}

Garrido, Ana ^{[2
,3
]}

Navarro, Blanca ^{[1
]}

Nomdedeu, Josep ^{[2
,3
]}

Sierra, Jordi ^{[2
,3
]}

Tormo, Mar ^{[1
]}

机构：

[1] Hosp Clin Univ INCLIVA Biomed Res Inst, Dept Hematol & Med Oncol, Valencia, Spain

[2] Univ Autonoma Barcelona, Dept Hematol, Hosp St Pau, IIB St Pau Leukemia Res Inst, Barcelona, Spain

[3] Univ Autonoma Barcelona, Dept Hematol, Hosp St Pau, Jose Carreras Leukemia Res Inst, Barcelona, Spain

[4] IDIBAPS, Hosp Clin, Dept Hematol, Barcelona, Spain

[5] Hosp Univ Joan XIII, Dept Hematol, Tarragona, Spain

[6] Hosp Josep Trueta, IDIBGI Fdn, ICO Girona, Dept Hematol, Girona, Spain

[7] Univ Autonoma Barcelona, Josep Carreras Leukemia Res Inst, Hosp Germans Trias & Pujol, Dept Hematol,ICO Badalona, Badalona, Spain

[8] Hosp Virgen Victoria, Dept Hematol, Malaga, Spain

[9] Hosp Duran i Reynals, Dept Hematol, ICO, Barcelona, Spain

[10] Hosp del Mar, Dept Hematol, Parc Salut Mar, Barcelona, Spain

[11] Hosp Morales Meseguer, Dept Hematol, Murcia, Spain

[12] Hosp Univ Mutua Terrassa, Terrassa, Spain

[13] Hosp Univ Arnau Villanova, Dept Hematol, Lleida, Spain

[14] Hosp Son Llatzer, Dept Hematol, Mallorca, Spain

[15] Univ Hosp Son Espases, Inst IDISPA, Dept Hematol, Palma De Mallorca, Spain

[16] Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain

[17] Hosp Verge Cinta, Dept Hematol, Tortosa, Spain

来源：

LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 10期

关键词：

Acute myeloid leukemia; VEGFC expression; VEGF signaling; FLT1; KDR; NRP1; GROWTH-FACTOR VEGF; GENE-EXPRESSION; CELL GROWTH; ANGIOGENESIS; MIGRATION; PROLIFERATION; DIAGNOSIS; DISEASE; FLT-1; PCR;

D O I：

10.1080/10428194.2017.1422858

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial growth factor C (VEGFC) stimulates leukemia cell proliferation and survival, and promotes angiogenesis. We studied VEGFC expression in bone marrow samples from 353 adult acute myeloid leukemia (AML) patients and its relationship with several clinical, cytogenetic, and molecular variables. We also studied the expression of 84 genes involved in VEGF signaling in 24 patients. We found that VEGFC expression was higher in AML patients with myelodysplasia-related changes (AML-MRC) than in patients with non-AML-MRC. We also found an association between VEGFC expression and the patient cytogenetic risk group, with those with a worse prognosis having higher VEGFC expression levels. No correlation was observed between VEGFC expression and survival or complete remission. VEGFC expression strongly correlated with expression of the VEGF receptors FLT1, KDR, and NRP1. Thus, in this series, VEGFC expression was increased in AML-MRC and in subgroups with a poorer prognosis, but has no impact on survival.

引用

页码：2383 / 2393

页数：11

共 50 条

[31] Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia
Yamato, Genki
Yamaguchi, Hiroki
Handa, Hiroshi
Shiba, Norio
Kawamura, Machiko
Wakita, Satoshi
Inokuchi, Koiti
Hara, Yusuke
Ohki, Kentaro
Okubo, Jun
Park, Myoung-Ja
Sotomatsu, Manabu
Arakawa, Hirokazu
Hayashi, Yasuhide
GENES CHROMOSOMES & CANCER, 2017, 56 (11) : 800 - 809
[32] The prospective prognostic value of the immune checkpoint BTLA expression in adult acute myeloid leukemia patients
Radwan, Sara M.
Elleboudy, Nooran S.
Nabih, Nermeen A.
El-kholy, Amal
Kamal, Amany M.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS, 2021, 22 (01)
[33] Impact of pre-transplant bone marrow blast percentage on survival in acute myeloid leukemia patients
Ciftciler, Rafiye
Goker, Hakan
Buyukasik, Yahya
Malkan, Umit Yavuz
Saglam, Emine Arzu
Demiroglu, Haluk
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (07): : 9288 - 9294
[34] Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression
Teng, Teng
Ren, Liping
Xiao, Jilong
Shi, Zhiyu
Li, Lanbo
Song, Chunhong
FRONTIERS IN ONCOLOGY, 2024, 14
[35] The prospective prognostic value of the immune checkpoint BTLA expression in adult acute myeloid leukemia patients
Sara M. Radwan
Nooran S. Elleboudy
Nermeen A. Nabih
Amal El-kholy
Amany M. Kamal
Egyptian Journal of Medical Human Genetics, 22
[36] High expression of FCHSD2 is associated with chemoresistance in adult acute myeloid leukemia
El Dahshan D.
Metwaly H.
Sheir R.
Aly T.
Comparative Clinical Pathology, 2014, 23 (5) : 1441 - 1446
[37] Prognostic significance of WT1 expression at diagnosis and end of induction in Egyptian adult acute myeloid leukemia patients
Mossallam, Ghada I.
Hamid, Thoraya M. Abdel
Mahmoud, Hossam K.
HEMATOLOGY, 2013, 18 (02) : 69 - 73
[38] Expression Pattern and Prognostic Significance of EVI1 Gene in Adult Acute Myeloid Leukemia Patients with Normal Karyotype
Marjanovic, Irena
Karan-Djurasevic, Teodora
Kostic, Tatjana
Virijevic, Marijana
Suvajdzic-Vukovic, Nada
Pavlovic, Sonja
Tosic, Natasa
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2020, 36 (02) : 292 - 299
[39] Prognostic significance of vascular endothelial growth factor expression in adult patients with acute myeloid leukemia: a meta-analysis
Guo, Baoping
Liu, Yan
Tan, Xiaohong
Cen, Hong
LEUKEMIA & LYMPHOMA, 2013, 54 (07) : 1418 - 1425
[40] High expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemia
Kuehnl, Andrea
Kaiser, Martin
Neumann, Martin
Fransecky, Lars
Heesch, Sandra
Radmacher, Michael
Marcucci, Guido
Bloomfield, Clara D.
Hofmann, Wolf-Karsten
Thiel, Eckhard
Baldus, Claudia D.
LEUKEMIA RESEARCH, 2011, 35 (12) : 1585 - 1590

← 1 2 3 4 5 →