Bone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival

被引：0

作者：

Guillem, Vicent ^{[1
]}

Calabuig, Marisa ^{[1
]}

Brunet, Salut ^{[2
,3
]}

Esteve, Jordi ^{[4
]}

Escoda, Lourdes ^{[5
]}

Gallardo, David ^{[6
]}

Ribera, Josep-Maria ^{[7
]}

Queipo de Llano, Maria Paz ^{[8
]}

Arnan, Montserrat ^{[9
]}

Pedro, Carme ^{[10
]}

Luz Amigo, Maria ^{[11
]}

Marti-Tutusaus, Josep M. ^{[12
]}

Garcia-Guinon, Antoni ^{[13
]}

Bargay, Joan ^{[14
]}

Sampol, Antonia ^{[15
]}

Salamero, Olga ^{[16
]}

Font, Llorenc ^{[17
]}

Talarn, Carme ^{[4
]}

Hoyos, Montserrat ^{[2
,3
]}

Diaz-Beya, Marina ^{[4
]}

Garrido, Ana ^{[2
,3
]}

Navarro, Blanca ^{[1
]}

Nomdedeu, Josep ^{[2
,3
]}

Sierra, Jordi ^{[2
,3
]}

Tormo, Mar ^{[1
]}

机构：

[1] Hosp Clin Univ INCLIVA Biomed Res Inst, Dept Hematol & Med Oncol, Valencia, Spain

[2] Univ Autonoma Barcelona, Dept Hematol, Hosp St Pau, IIB St Pau Leukemia Res Inst, Barcelona, Spain

[3] Univ Autonoma Barcelona, Dept Hematol, Hosp St Pau, Jose Carreras Leukemia Res Inst, Barcelona, Spain

[4] IDIBAPS, Hosp Clin, Dept Hematol, Barcelona, Spain

[5] Hosp Univ Joan XIII, Dept Hematol, Tarragona, Spain

[6] Hosp Josep Trueta, IDIBGI Fdn, ICO Girona, Dept Hematol, Girona, Spain

[7] Univ Autonoma Barcelona, Josep Carreras Leukemia Res Inst, Hosp Germans Trias & Pujol, Dept Hematol,ICO Badalona, Badalona, Spain

[8] Hosp Virgen Victoria, Dept Hematol, Malaga, Spain

[9] Hosp Duran i Reynals, Dept Hematol, ICO, Barcelona, Spain

[10] Hosp del Mar, Dept Hematol, Parc Salut Mar, Barcelona, Spain

[11] Hosp Morales Meseguer, Dept Hematol, Murcia, Spain

[12] Hosp Univ Mutua Terrassa, Terrassa, Spain

[13] Hosp Univ Arnau Villanova, Dept Hematol, Lleida, Spain

[14] Hosp Son Llatzer, Dept Hematol, Mallorca, Spain

[15] Univ Hosp Son Espases, Inst IDISPA, Dept Hematol, Palma De Mallorca, Spain

[16] Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain

[17] Hosp Verge Cinta, Dept Hematol, Tortosa, Spain

来源：

LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 10期

关键词：

Acute myeloid leukemia; VEGFC expression; VEGF signaling; FLT1; KDR; NRP1; GROWTH-FACTOR VEGF; GENE-EXPRESSION; CELL GROWTH; ANGIOGENESIS; MIGRATION; PROLIFERATION; DIAGNOSIS; DISEASE; FLT-1; PCR;

D O I：

10.1080/10428194.2017.1422858

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial growth factor C (VEGFC) stimulates leukemia cell proliferation and survival, and promotes angiogenesis. We studied VEGFC expression in bone marrow samples from 353 adult acute myeloid leukemia (AML) patients and its relationship with several clinical, cytogenetic, and molecular variables. We also studied the expression of 84 genes involved in VEGF signaling in 24 patients. We found that VEGFC expression was higher in AML patients with myelodysplasia-related changes (AML-MRC) than in patients with non-AML-MRC. We also found an association between VEGFC expression and the patient cytogenetic risk group, with those with a worse prognosis having higher VEGFC expression levels. No correlation was observed between VEGFC expression and survival or complete remission. VEGFC expression strongly correlated with expression of the VEGF receptors FLT1, KDR, and NRP1. Thus, in this series, VEGFC expression was increased in AML-MRC and in subgroups with a poorer prognosis, but has no impact on survival.

引用

页码：2383 / 2393

页数：11

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