Dendritic cells as cancer therapeutics

被引：51

作者：

Bryant, Christian E. ^{[1
,2
]}

Sutherland, Sarah ^{[2
,3
]}

Kong, Benjamin ^{[2
,3
]}

Papadimitrious, Michael S. ^{[2
,3
]}

Fromm, Phillip D. ^{[2
,3
]}

Hart, Derek N. J. ^{[1
,2
,3
]}

机构：

[1] Royal Prince Alfred Hosp, Inst Haematol, Camperdown, NSW, Australia

[2] ANZAC Res Inst, Dendrit Cell Res, Gate 3 Hosp Rd, Concord, NSW 2139, Australia

[3] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2019年 / 86卷

基金：

英国医学研究理事会;

关键词：

Dendritic cell; Vaccine; Immunotherapy; Cancer; ACUTE MYELOID-LEUKEMIA; METASTATIC MELANOMA PATIENTS; CYTOTOXIC T-LYMPHOCYTES; REFRACTORY PROSTATE-CANCER; COLONY-STIMULATING FACTOR; INFLAMED LYMPH-NODES; I CLINICAL-TRIAL; MHC CLASS-I; MESSENGER-RNA; ANTIGEN PRESENTATION;

D O I：

10.1016/j.semcdb.2018.02.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ability of immune therapies to control cancer has recently generated intense interest. This therapeutic outcome is reliant on T cell recognition of tumour cells. The natural function of dendritic cells (DC) is to generate adaptive responses, by presenting antigen to T cells, hence they are a logical target to generate specific anti-tumour immunity. Our understanding of the biology of DC is expanding, and they are now known to be a family of related subsets with variable features and function. Most clinical experience to date with DC vaccination has been using monocyte-derived DC vaccines. There is now growing experience with alternative blood-derived DC derived vaccines, as well as with multiple forms of tumour antigen and its loading, a wide range of adjuvants and different modes of vaccine delivery. Key insights from pre-clinical studies, and lessons learned from early clinical testing drive progress towards improved vaccines. The potential to fortify responses with other modalities of immunotherapy makes clinically effective "second generation" DC vaccination strategies a priority for cancer immune therapists. (C) 2018 Published by Elsevier Ltd.

引用

页码：77 / 88

页数：12

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