A portable albumin binder from a DNA-encoded chemical library

被引：180

作者：

Dumelin, Christoph E. ^{[2
]}

Truessel, Sabrina ^{[1
,2
]}

Buller, Fabian ^{[1
]}

Trachsel, Eveline

Bootz, Frank ^{[1
]}

Zhang, Yixin ^{[1
]}

Mannocci, Luca ^{[1
]}

Beck, Susanne C. ^{[3
]}

Drumea-Mirancea, Mihaela ^{[3
]}

Seeliger, Mathias W. ^{[3
]}

Baltes, Christof ^{[4
]}

Mueggler, Thomas ^{[4
]}

Kranz, Felicitas ^{[4
]}

Rudin, Markus ^{[4
]}

Melkko, Samu ^{[2
]}

Scheuermann, Joerg ^{[1
]}

Neri, Dario ^{[1
]}

机构：

[1] ETH, Inst Pharmazeut Wissensch, Dept Chem & Angew Biowissensch, CH-8093 Zurich, Switzerland

[2] ETH, Philochem AG, CH-8093 Zurich, Switzerland

[3] Univ Klinikum Tubingen, AG Neurodegenerat Auges, Forsch Inst Augenheilkunde, Dept Augenheilkunde, D-72076 Tubingen, Germany

[4] Univ Zurich, Dept Electrotech, Inst Biomed Tech, Anim Imaging Ctr, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 17期

关键词：

compound libraries; imaging agents; pharmacokinetics; proteins; structure-activity relationships;

D O I：

10.1002/anie.200704936

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Seeing eye to eye: Plasma-protein binding is effective in improving the pharmacokinetic properties of otherwise short-lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half-life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3196 / 3201

页数：6