A portable albumin binder from a DNA-encoded chemical library

被引：178

作者：

Dumelin, Christoph E. ^{[2
]}

Truessel, Sabrina ^{[1
,2
]}

Buller, Fabian ^{[1
]}

Trachsel, Eveline

Bootz, Frank ^{[1
]}

Zhang, Yixin ^{[1
]}

Mannocci, Luca ^{[1
]}

Beck, Susanne C. ^{[3
]}

Drumea-Mirancea, Mihaela ^{[3
]}

Seeliger, Mathias W. ^{[3
]}

Baltes, Christof ^{[4
]}

Mueggler, Thomas ^{[4
]}

Kranz, Felicitas ^{[4
]}

Rudin, Markus ^{[4
]}

Melkko, Samu ^{[2
]}

Scheuermann, Joerg ^{[1
]}

Neri, Dario ^{[1
]}

机构：

[1] ETH, Inst Pharmazeut Wissensch, Dept Chem & Angew Biowissensch, CH-8093 Zurich, Switzerland

[2] ETH, Philochem AG, CH-8093 Zurich, Switzerland

[3] Univ Klinikum Tubingen, AG Neurodegenerat Auges, Forsch Inst Augenheilkunde, Dept Augenheilkunde, D-72076 Tubingen, Germany

[4] Univ Zurich, Dept Electrotech, Inst Biomed Tech, Anim Imaging Ctr, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 17期

关键词：

compound libraries; imaging agents; pharmacokinetics; proteins; structure-activity relationships;

D O I：

10.1002/anie.200704936

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Seeing eye to eye: Plasma-protein binding is effective in improving the pharmacokinetic properties of otherwise short-lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half-life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3196 / 3201

页数：6

共 27 条

[21] Radioiodinated Portable Albumin Binder as a Versatile Agent for in Vivo Imaging with Single-Photon Emission Computed Tomography
Wen, Xuejun
Shi, Changrong
Xu, Duo
Zhang, Pu
Li, Zizhen
Li, Jindian
Su, Xinhui
Zhuang, Rongqiang
Liu, Ting
Guo, Zhide
Zhang, Xianzhong
MOLECULAR PHARMACEUTICS, 2019, 16 (02) : 816 - 824
[22] Second-generation DNA-encoded multiple display on a constant macrocyclic scaffold enabled by an orthogonal protecting group strategy
Nie, Qigui
Zhong, Shuting
Li, Yangfeng
Zhang, Gong
Li, Yizhou
CHINESE CHEMICAL LETTERS, 2022, 33 (05) : 2559 - 2563
[23] Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA
Lin, Chenxiang
Jungmann, Ralf
Leifer, Andrew M.
Li, Chao
Levner, Daniel
Church, George M.
Shih, William M.
Yin, Peng
NATURE CHEMISTRY, 2012, 4 (10) : 832 - 839
[24] Screening and Identification of a Novel Esterase EstPE from a Metagenomic DNA Library
Park, So-Youn
Shin, Hyun-Jae
Kim, Geun-Joong
JOURNAL OF MICROBIOLOGY, 2011, 49 (01) : 7 - 14
[25] Reconsidering the role of albumin towards amorphous calcium phosphate-based calciprotein particles formation and stability from a physico-chemical perspective
Gelli, Rita
Ridi, Francesca
COLLOIDS AND SURFACES B-BIOINTERFACES, 2023, 227
[26] Identification of novel bioactive compounds from Olea europaea by evaluation of chemical compounds in the OliveNet™ library: in silico bioactivity and molecular modelling, and in vitro validation of hERG activity
Pitsillou, Eleni
Liang, Julia J.
Beh, Raymond C.
Prestedge, Jacqueline
Catak, Seda
Hung, Andrew
Karagiannis, Tom C.
COMPUTERS IN BIOLOGY AND MEDICINE, 2022, 142
[27] Accurate quantification of 5-Methylcytosine, 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine in genomic DNA from breast cancer by chemical derivatization coupled with ultra performance liquid chromatography-electrospray quadrupole time of flight mass spectrometry analysis
Guo, Mengzhe
Li, Xiao
Zhang, Liyan
Liu, Dantong
Du, Wencheng
Yin, Dengyang
Lyu, Nan
Zhao, Guangyu
Guo, Cheng
Tang, Daoquan
ONCOTARGET, 2017, 8 (53) : 91248 - 91257

← 1 2 3 →