Control of GnRH secretion: One step back

被引：65
作者：
Clarke, Iain J. [1 ]
机构：
[1] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2011年 / 32卷 / 03期
关键词：
Gonadotropin releasing hormone; RF-amide peptide; Reproduction; Food intake; Hypothalamus; GONADOTROPIN-RELEASING-HORMONE; RFAMIDE-RELATED PEPTIDE-3; ESTROGEN-POSITIVE FEEDBACK; MAMMALIAN NEUROENDOCRINE CELLS; GREEN FLUORESCENT PROTEIN; MESSENGER-RNA EXPRESSION; OVINE PREOPTIC AREA; LUTEINIZING-HORMONE; INHIBITORY HORMONE; LH-SECRETION;
D O I：
10.1016/j.yfrne.2011.01.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The reproductive system is controlled by gonadotropin releasing hormone (GnRH) secretion from the brain, which is finely modulated by a number of factors including gonadal sex steroids. GnRH cells do not express estrogen receptor a, but feedback is transmitted by neurons that are at least 'one step back' from the GnRH cells. Modulation by season, stress and nutrition are effected by neuronal pathways that converge on the GnRH cells. Kisspeptin and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion, the former being a major conduit for transmission of sex steroid feedback. GnIH cells project to GnRH cells and may play a role in the seasonal changes in reproductive activity in sheep. GnIH also modulates the action of GnRH at the level of the pituitary gonadotrope. This review focuses on the role that kisspeptin and GnIH neurons play, as modulators that are 'one step back' from GnRH neurons. (C) 2011 Elsevier Inc. All rights reserved.
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收藏
页码：367 / 375
页数：9
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