Control of GnRH secretion: One step back

被引：65
作者：
Clarke, Iain J. [1 ]
机构：
[1] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2011年 / 32卷 / 03期
关键词：
Gonadotropin releasing hormone; RF-amide peptide; Reproduction; Food intake; Hypothalamus; GONADOTROPIN-RELEASING-HORMONE; RFAMIDE-RELATED PEPTIDE-3; ESTROGEN-POSITIVE FEEDBACK; MAMMALIAN NEUROENDOCRINE CELLS; GREEN FLUORESCENT PROTEIN; MESSENGER-RNA EXPRESSION; OVINE PREOPTIC AREA; LUTEINIZING-HORMONE; INHIBITORY HORMONE; LH-SECRETION;
D O I：
10.1016/j.yfrne.2011.01.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The reproductive system is controlled by gonadotropin releasing hormone (GnRH) secretion from the brain, which is finely modulated by a number of factors including gonadal sex steroids. GnRH cells do not express estrogen receptor a, but feedback is transmitted by neurons that are at least 'one step back' from the GnRH cells. Modulation by season, stress and nutrition are effected by neuronal pathways that converge on the GnRH cells. Kisspeptin and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion, the former being a major conduit for transmission of sex steroid feedback. GnIH cells project to GnRH cells and may play a role in the seasonal changes in reproductive activity in sheep. GnIH also modulates the action of GnRH at the level of the pituitary gonadotrope. This review focuses on the role that kisspeptin and GnIH neurons play, as modulators that are 'one step back' from GnRH neurons. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：367 / 375
页数：9
相关论文
共 141 条
  • [1] Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats
    Adachi, Sachika
    Yamada, Shunji
    Takatsu, Yoshihiro
    Matsui, Hisanori
    Kinoshita, Mika
    Takase, Kenji
    Sugiura, Hitomi
    Ohtaki, Tetsuya
    Matsumoto, Hirokazu
    Uenoyama, Yoshihisa
    Tsukamura, Hiroko
    Inoue, Kinji
    Maeda, Kei-Ichiro
    [J]. JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2007, 53 (02) : 367 - 378
  • [2] PURIFICATION, AMINO ACID COMPOSITION AND N-TERMINUS OF HYPOTHALAMIC LUTEINIZING HORMONE RELEASING FACTOR (LRF) OF OVINE ORIGIN
    AMOSS, M
    BURGUS, R
    BLACKWELL, R
    VALE, W
    FELLOWS, R
    GUILLEMIN, R
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1971, 44 (01) : 205 - +
  • [3] Central and Peripheral Effects of RFamide-Related Peptide-3 on Luteinizing Hormone and Prolactin Secretion in Rats
    Anderson, Greg M.
    Relf, Hana-Lee
    Rizwan, Mohammed Z.
    Evans, John J.
    [J]. ENDOCRINOLOGY, 2009, 150 (04) : 1834 - 1840
  • [4] BURST DISCHARGE IN MAMMALIAN NEUROENDOCRINE CELLS INVOLVES AN INTRINSIC REGENERATIVE MECHANISM
    ANDREW, RD
    DUDEK, FE
    [J]. SCIENCE, 1983, 221 (4615) : 1050 - 1052
  • [5] ANALYSIS OF INTRACELLULARLY RECORDED PHASIC BURSTING BY MAMMALIAN NEUROENDOCRINE CELLS
    ANDREW, RD
    DUDEK, FE
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1984, 51 (03) : 552 - 566
  • [6] Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats
    Asarian, L
    Geary, N
    [J]. HORMONES AND BEHAVIOR, 2002, 42 (04) : 461 - 471
  • [7] Kisspeptin Cells in the Ewe Brain Respond to Leptin and Communicate with Neuropeptide Y and Proopiomelanocortin Cells
    Backholer, Kathryn
    Smith, Jeremy T.
    Rao, Alix
    Pereira, Alda
    Iqbal, Javed
    Ogawa, Satoshi
    Li, Qun
    Clarke, Iain J.
    [J]. ENDOCRINOLOGY, 2010, 151 (05) : 2233 - 2243
  • [8] Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes
    Backholer, Kathryn
    Bowden, Marissa
    Gamber, Kevin
    Bjorbaek, Christian
    Iqbal, Javed
    Clarke, Iain J.
    [J]. NEUROENDOCRINOLOGY, 2010, 91 (01) : 27 - 40
  • [9] Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe
    Backholer, Kathryn
    Smith, Jeremy
    Clarke, Iain J.
    [J]. ENDOCRINOLOGY, 2009, 150 (12) : 5488 - 5497
  • [10] THE ROLE OF NEUROPEPTIDE-Y (NPY) IN THE CONTROL OF LH-SECRETION IN THE EWE WITH RESPECT TO SEASON, NPY RECEPTOR SUBTYPE AND THE SITE OF ACTION IN THE HYPOTHALAMUS
    BARKERGIBB, ML
    SCOTT, CJ
    BOUBLIK, JH
    CLARKE, IJ
    [J]. JOURNAL OF ENDOCRINOLOGY, 1995, 147 (03) : 565 - 579
12345678910