Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury

被引：62
作者：
Wu, Shou-yan [1 ,2 ]
Wang, Wen-jie [1 ,2 ]
Dou, Jin-hui [3 ]
Gong, Li-kun [1 ,2 ]
机构：
[1] Chinese Acad Sci, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Oxford, MS 38677 USA
来源：
ACTA PHARMACOLOGICA SINICA | 2021年 / 42卷 / 01期
关键词：
18 beta-glycyrrhetic acid; licorice preparation; liver injury; glycyrrhetinic acid target; ALPHA-NAPHTHYL ISOTHIOCYANATE; HEPATIC STELLATE CELLS; NF-KAPPA-B; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; IN-VITRO; INDUCED HEPATOTOXICITY; DOWN-REGULATION; GLOBAL BURDEN; APOPTOSIS;
D O I：
10.1038/s41401-020-0383-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first description of the medical use of licorice appeared in "Shennong Bencao Jing", one of the well-known Chinese herbal medicine classic books dated back to 220-280 AD. As one of the most commonly prescribed Chinese herbal medicine, licorice is known as "Guo Lao", meaning "a national treasure" in China. Modern pharmacological investigations have confirmed that licorice possesses a number of biological activities, such as antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection. 18 beta-glycyrrhetinic acid is one of the most extensively studied active integrants of licorice. Here, we provide an overview of the protective effects of 18 beta-glycyrrhetinic acid against various acute and chronic liver diseases observed in experimental models, and summarize its pharmacological effects and potential toxic/side effects at higher doses. We also make additional comments on the important areas that may warrant further research to support appropriate clinical applications of 18 beta-glycyrrhetinic acid and avoid potential risks.
引用
收藏
页码：18 / 26
页数：9
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