ZnCl2-Catalyzed [3+2] Cycloaddition of Benzimidates and 2H-Azirines for the Synthesis of Imidazoles

被引：41

作者：

Shi, Shoujie ^{[1
]}

Xu, Kang ^{[1
]}

Jiang, Cheng ^{[1
]}

Ding, Zhenhua ^{[1
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Dept Med Chem, Sch Pharm, Nanjing 210009, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 23期

基金：

中国国家自然科学基金;

关键词：

PYRROLE SYNTHESIS; PYRIDINES; REARRANGEMENT; EXPANSION; PYRAZINES; CLEAVAGE; ALKYNES;

D O I：

10.1021/acs.joc.8b02437

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

ZnCl2-catalyzed [3 + 2] cycloaddition reaction of benzimidates and 2H-azirines has been developed. This convenient method allowed the efficient construction of a series of multisubstituted imidazoles in moderate to good yields under mild reaction conditions. This transformation exhibits good reactivity and high functional group tolerance.

引用

收藏

页码：14791 / 14796

页数：6

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