Hypersensitivity to sub-Tenon's topotecan in fibrin adhesive in patients with retinoblastoma

被引：4

作者：

Astudillo, Paulita Pamela P. ^{[1
,2
]}

Durairaj, Priya ^{[3
]}

Chan, Helen S. L. ^{[4
,5
]}

Heon, Elise ^{[1
,2
]}

Gallie, Brenda L. ^{[1
,2
,3
,6
,7
]}

机构：

[1] Hosp Sick Children, Dept Ophthalmol & Visual Sci, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Ophthalmol & Visual Sci, Toronto, ON M5S 1A1, Canada

[3] Univ Hlth Network, Princess Margaret Hosp, Toronto, ON, Canada

[4] Hosp Sick Children, Dept Pediat, Div Hematol Oncol, Toronto, ON M5G 1X8, Canada

[5] Univ Toronto, Dept Pediat, Toronto, ON M5S 1A1, Canada

[6] Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A1, Canada

[7] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada

来源：

JOURNAL OF AAPOS | 2015年 / 19卷 / 01期

关键词：

SEALANT; APROTININ;

D O I：

10.1016/j.jaapos.2014.09.018

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Sub-Tenon's space delivery of topotecan in a fibrin sealant was used as an adjunct to laser therapy for small retinoblastoma tumors in 25 children (77 injections). We report serious hypersensitivity reactions in 2 children on their third sub-Tenon's injection of topotecan in fibrin sealant. One child subsequently had topotecan in an autologous blood clot with no allergic reaction. Although allergic reaction to topotecan has been reported in the literature, fibrin glue reactions are more common and are likely due to aprotinin hypersensitivity.

引用

页码：86 / 87

页数：2

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