The 20th anniversary of proteomics and some of its origins

被引:6
作者
Humphery-Smith, Ian [1 ]
机构
[1] Skolkovo RusInnovat, Moscow 107045, Russia
关键词
Animal proteomics; Historical context; Proteome; Replication-induced protein synthesis; Signature peptides; Whole genome analysis; MYCOPLASMA-GENITALIUM;
D O I
10.1002/pmic.201400582
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The term proteome was first introduced into the scientific literature in July 1995. Almost 20 years ago attempts to characterize the total protein complement able to be encoded by a given genome only became possible due to privileged access to what were then the world's most complete sets of genomic data. Today, proteomics has become an important pillar in the fields of disease diagnosis and drug research and development, while also playing a critical role in the much larger field of Healthcare Analytics and Biomarker Discovery and Detection. It is important to note that this industry originated mostly from building blocks in analytical science that predated the term proteomics by many decades. However, proteomics, as a discipline, has allowed protein scientists to more favorably compete in the face of highly fashionable Big Science and, more specifically, genomics.
引用
收藏
页码:1773 / 1776
页数:4
相关论文
共 18 条
  • [1] And now for the proteome ...
    Abbott, A
    [J]. NATURE, 2001, 409 (6822) : 747 - 747
  • [2] Albala J. S., 2003, P CORR C SAN DIEG CA, P1
  • [3] Six decades searching for meaning in the proteome
    Anderson, Leigh
    [J]. JOURNAL OF PROTEOMICS, 2014, 107 : 24 - 30
  • [4] The magic of words
    Calvete, Juan J.
    Bini, Luca
    Hochstrasser, Denis
    Sanchez, Jean-Charles
    Turck, Natacha
    [J]. JOURNAL OF PROTEOMICS, 2014, 107 : 1 - 4
  • [5] A personal account of the early stages of proteomics at Aarhus University
    Celis, Julio E.
    [J]. JOURNAL OF PROTEOMICS, 2014, 107 : 31 - 38
  • [6] WHOLE-GENOME RANDOM SEQUENCING AND ASSEMBLY OF HAEMOPHILUS-INFLUENZAE RD
    FLEISCHMANN, RD
    ADAMS, MD
    WHITE, O
    CLAYTON, RA
    KIRKNESS, EF
    KERLAVAGE, AR
    BULT, CJ
    TOMB, JF
    DOUGHERTY, BA
    MERRICK, JM
    MCKENNEY, K
    SUTTON, G
    FITZHUGH, W
    FIELDS, C
    GOCAYNE, JD
    SCOTT, J
    SHIRLEY, R
    LIU, LI
    GLODEK, A
    KELLEY, JM
    WEIDMAN, JF
    PHILLIPS, CA
    SPRIGGS, T
    HEDBLOM, E
    COTTON, MD
    UTTERBACK, TR
    HANNA, MC
    NGUYEN, DT
    SAUDEK, DM
    BRANDON, RC
    FINE, LD
    FRITCHMAN, JL
    FUHRMANN, JL
    GEOGHAGEN, NSM
    GNEHM, CL
    MCDONALD, LA
    SMALL, KV
    FRASER, CM
    SMITH, HO
    VENTER, JC
    [J]. SCIENCE, 1995, 269 (5223) : 496 - 512
  • [7] THE MINIMAL GENE COMPLEMENT OF MYCOPLASMA-GENITALIUM
    FRASER, CM
    GOCAYNE, JD
    WHITE, O
    ADAMS, MD
    CLAYTON, RA
    FLEISCHMANN, RD
    BULT, CJ
    KERLAVAGE, AR
    SUTTON, G
    KELLEY, JM
    FRITCHMAN, JL
    WEIDMAN, JF
    SMALL, KV
    SANDUSKY, M
    FUHRMANN, J
    NGUYEN, D
    UTTERBACK, TR
    SAUDEK, DM
    PHILLIPS, CA
    MERRICK, JM
    TOMB, JF
    DOUGHERTY, BA
    BOTT, KF
    HU, PC
    LUCIER, TS
    PETERSON, SN
    SMITH, HO
    HUTCHISON, CA
    VENTER, JC
    [J]. SCIENCE, 1995, 270 (5235) : 397 - 403
  • [8] Humphery-Smith I, 1999, ELECTROPHORESIS, V20, P653, DOI 10.1002/(SICI)1522-2683(19990101)20:4/5<653::AID-ELPS653>3.0.CO
  • [9] 2-I
  • [10] A human proteome project with a beginning and an end
    Humphery-Smith, I
    [J]. PROTEOMICS, 2004, 4 (09) : 2519 - 2521