Asymmetric conjugate addition reactions of Meldrum's acid derived acceptors employing chiral phosphoramidite ligands

被引：59

作者：

Watanabe, T ^{[1
]}

Knöpfel, TF ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 24期

关键词：

D O I：

10.1021/ol035575q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective conjugate addition reaction of Et2Zn to Meldrum's acid derived acceptors, mediated by a catalyst formed from Cu(O2CCF3)(2) and a phosphoramidite ligand, is reported. Adducts are obtained in useful yields and up to 94% ee.

引用

页码：4557 / 4558

页数：2

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