Morbidity and Mortality of Crystalloids Compared to Colloids in Critically Ill Surgical Patients A Subgroup Analysis of a Randomized Trial

被引:19
作者
Heming, Nicholas [1 ,2 ]
Lamothe, Laure [1 ,2 ]
Jaber, Samir [3 ]
Trouillet, Jean Louis [4 ]
Martin, Claude [5 ]
Chevret, Sylvie [6 ]
Annane, Djillali [1 ,2 ]
机构
[1] Hop Raymond Poincare, Gen Intens Care Unit, Garches, France
[2] Univ Versailles SQY Paris Saclay, INSERM, U1173, Lab Inflammat & Infect, Montigny Le Bretonneux, France
[3] St Eloi Hosp, Dept Anesthesiol & Crit Care Med B, Montpellier, France
[4] Hop La Pitie Salpetriere, Inst Cardiol, Intens Care Unit, Paris, France
[5] North Hosp, AP HM, Anaesthesiol Emergency Intens Care Unit Dept, Marseille, France
[6] St Louis Hosp, Biostat Unit, Paris, France
关键词
HYDROXYETHYL STARCH 130/0.4; EUROPEAN MEDICINES AGENCY; RENAL-FUNCTION; FLUID RESUSCITATION; EXECUTIVE DIRECTOR; ACUTE PHYSIOLOGY; CARDIAC-SURGERY; KIDNEY INJURY; BLOOD-LOSS; COAGULATION;
D O I
10.1097/ALN.0000000000002413
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: The multicenter randomized Colloids versus Crystalloids for the Resuscitation of the Critically Ill (CRIS-TAL) trial was designed to test whether colloids altered mortality compared to crystalloids in the resuscitation of intensive care unit patients with hypovolemic shock. This preplanned analysis tested the same hypothesis in the subgroup of surgical patients. Methods: The CRISTAL trial prospectively defined patients as critically ill surgical patients whenever they underwent emergency or scheduled surgery immediately before or within 24 h of intensive care unit admission and had hypovolemic shock. The primary outcome measure was death by day 28. Secondary outcome measures included death by day 90, the need for renal replacement therapy, or the need for fresh frozen plasma transfusion. Results: There were 741 critically ill surgical patients, 356 and 385 in the crystalloid and colloid arm, respectively. Median (interquartile range) age was 66 (52 to 76) yr, and 484 (65.3%) patients were male. Surgery was unscheduled in 543 (73.3%) cases. Mortality by day 28 did not significantly differ for crystalloids 84 (23.6%) versus colloids 100 (26%; adjusted odds ratio, 0.86; 95% CI, 0.61 to 1.21; P = 0.768). Death by day 90 (111 [31.2%] vs. 122 [31.7%]; adjusted odds ratio, 0.97; 95% CI, 0.70 to 1.33; P = 0.919) did not significantly differ between groups. Renal replacement therapy was required for 42 (11.8%) patients in the crystalloids arm versus 49 (12.7%) in the colloids arm (P = 0.871). Conclusions: The authors found no survival benefit when comparing crystalloids to colloids in critically ill surgical patients.
引用
收藏
页码:1149 / 1158
页数:10
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