Linkage analysis of angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and systemic lupus erythematosus

被引：53

作者：

Kaufman, KM

Kelly, J

Gray-McGuire, C

Asundi, N

Ya, H

Reid, J

Baird, T

Hutchings, D

Bruner, G

Scofield, RH

Moser, K

Harley, JB

机构：

[1] Oklahoma Med Res Fdn, Arthrit & Immunol Program, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK USA

[3] Univ Minnesota, Sch Med, Div Rheumatol, Oklahoma City, OK USA

[4] US Dept Vet Affairs, Med Ctr, Oklahoma City, OK USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2001年 / 177卷 / 1-2期

关键词：

systemic lupus erythematosus; linkage; angiotensin-converting enzyme (ACE);

D O I：

10.1016/S0303-7207(01)00424-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previous studies have suggested an association between systemic lupus erythematosus (SLE) and an insertion/deletion polymorphism in the angiotensin-converting enzyme gene (ACE). This polymorphism consists of a 250-bp insertion/deletion of an alu repeat in the 16th intron of the ACE gene. Individuals homozygous for the deletion have a higher level of circulating enzyme. Due to the important role of this enzyme in regulating the renin-angiotensin and kallikrein-kininogen systems, it is possible that the ACE insertion/deletion may play a role in SLE, which can include vasculitis and vascular changes. Using primers flanking the insertion/deletion site, we have examined the ACE gene in lupus patients and family members using genomic DNA obtained from the Lupus Multiplex Registry and Repository (LMRR). We were unable to detect significant linkage or genetic association between the ACE gene and SLE. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：81 / 85

页数：5

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