The basophil activation test in the diagnosis of immediate drug hypersensitivity

被引：2

作者：

Leysen, Julie ^{[1
]}

Sabato, Vito ^{[1
]}

Verweij, Marjoke M. ^{[1
]}

De Knop, Kathleen J. ^{[1
]}

Bridts, Chris H. ^{[1
]}

De Clerck, Luc S. ^{[1
]}

Ebo, Didier G. ^{[1
]}

机构：

[1] Univ Antwerp, Fac Med, Dept Immunol Allergol Rheumatol, B-2020 Antwerp, Belgium

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2011年 / 7卷 / 03期

关键词：

basophil activation test; CD203c; CD63; drug allergy; flow cytometry; specific IgE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; IN-VITRO DIAGNOSIS; CD63; EXPRESSION; ALLERGIC REACTIONS; SKIN-TESTS; ANAPHYLAXIS; IGE; CD203C; DEGRANULATION; MULTICENTER;

D O I：

10.1586/ECI.11.14

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hypersensitivity reactions to drugs account for 15% of all adverse drug reactions and represent an important health problem with significant morbidity and mortality. This article describes the current applications and perspectives of the basophil activation test by flow cytometry in the diagnosis of immediate-type drug allergy, with particular focus on its diagnostic performance in allergy to neuromuscular blocking agents, antibiotics and NSAIDs and on future applications.

引用

页码：349 / 355

页数：7

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